Proteasome activity correlates with male BMI and contributes to the differentiation of adipocyte in hADSC
We have previously reported that 26S proteasome subunit mRNA expressions correlate with male body mass index (BMI). In this study, to investigate whether proteasome activities are correlated with BMI, we recruited 61 healthy young Japanese male subjects, measured proteasome activities in their plasm...
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| Published in | Endocrine Vol. 37; no. 2; pp. 274 - 279 |
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| Format | Journal Article |
| Language | English |
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| Abstract | We have previously reported that 26S proteasome subunit mRNA expressions correlate with male body mass index (BMI). In this study, to investigate whether proteasome activities are correlated with BMI, we recruited 61 healthy young Japanese male subjects, measured proteasome activities in their plasma, and correlated them with their BMI and various metabolic factors. We found that among three different proteasome activities, chymotrypsin-like activity in plasma was positively correlated with BMI in healthy Japanese male subjects. Furthermore, we analyzed proteasome activity in vitro during the differentiation of human adipose-derived stem cell (hADSC) into mature adipocytes. In the early stage of differentiation, proteasome activity was at its highest level, and proteasome inhibitor could inhibit hADSC adipocyte differentiation. Our findings suggest that proteasome is an important controlling factor for the development of obesity and adipogenesis. |
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| AbstractList | We have previously reported that 26S proteasome subunit mRNA expressions correlate with male body mass index (BMI). In this study, to investigate whether proteasome activities are correlated with BMI, we recruited 61 healthy young Japanese male subjects, measured proteasome activities in their plasma, and correlated them with their BMI and various metabolic factors. We found that among three different proteasome activities, chymotrypsin-like activity in plasma was positively correlated with BMI in healthy Japanese male subjects. Furthermore, we analyzed proteasome activity in vitro during the differentiation of human adipose-derived stem cell (hADSC) into mature adipocytes. In the early stage of differentiation, proteasome activity was at its highest level, and proteasome inhibitor could inhibit hADSC adipocyte differentiation. Our findings suggest that proteasome is an important controlling factor for the development of obesity and adipogenesis. We have previously reported that 26S proteasome subunit mRNA expressions correlate with male body mass index (BMI). In this study, to investigate whether proteasome activities are correlated with BMI, we recruited 61 healthy young Japanese male subjects, measured proteasome activities in their plasma, and correlated them with their BMI and various metabolic factors. We found that among three different proteasome activities, chymotrypsin-like activity in plasma was positively correlated with BMI in healthy Japanese male subjects. Furthermore, we analyzed proteasome activity in vitro during the differentiation of human adipose-derived stem cell (hADSC) into mature adipocytes. In the early stage of differentiation, proteasome activity was at its highest level, and proteasome inhibitor could inhibit hADSC adipocyte differentiation. Our findings suggest that proteasome is an important controlling factor for the development of obesity and adipogenesis.We have previously reported that 26S proteasome subunit mRNA expressions correlate with male body mass index (BMI). In this study, to investigate whether proteasome activities are correlated with BMI, we recruited 61 healthy young Japanese male subjects, measured proteasome activities in their plasma, and correlated them with their BMI and various metabolic factors. We found that among three different proteasome activities, chymotrypsin-like activity in plasma was positively correlated with BMI in healthy Japanese male subjects. Furthermore, we analyzed proteasome activity in vitro during the differentiation of human adipose-derived stem cell (hADSC) into mature adipocytes. In the early stage of differentiation, proteasome activity was at its highest level, and proteasome inhibitor could inhibit hADSC adipocyte differentiation. Our findings suggest that proteasome is an important controlling factor for the development of obesity and adipogenesis. |
| Author | Ewis, Ashraf A Nakahori, Yutaka Sakamoto, Kozue Sato, Youichi Sei, Masako |
| Author_xml | – sequence: 1 fullname: Sakamoto, Kozue – sequence: 2 fullname: Sato, Youichi – sequence: 3 fullname: Sei, Masako – sequence: 4 fullname: Ewis, Ashraf A – sequence: 5 fullname: Nakahori, Yutaka |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20960262$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1111_jcmm_12194 crossref_primary_10_7124_bc_0008C3 crossref_primary_10_1089_scd_2011_0040 crossref_primary_10_4161_adip_28307 crossref_primary_10_1016_j_freeradbiomed_2011_08_001 crossref_primary_10_1186_1746_6148_10_146 crossref_primary_10_1038_s41598_023_49996_0 crossref_primary_10_1038_srep19752 crossref_primary_10_1002_biof_2157 crossref_primary_10_1016_j_bbamcr_2012_06_009 crossref_primary_10_1080_08941939_2020_1863527 crossref_primary_10_1152_ajpregu_00498_2016 |
| Cites_doi | 10.1126/science.274.5293.1652 10.1152/ajpcell.00333.2007 10.3177/jnsv.47.1 10.1074/jbc.M109996200 10.1038/sj.ijo.0802210 10.1016/S0962-8924(98)01346-4 10.1016/S1097-2765(00)80210-5 10.1023/A:1006876904158 10.1038/ng0397-269 10.1016/j.yexcr.2007.12.022 10.1006/bbrc.1993.2378 10.1016/S0076-6879(05)98030-0 10.1016/0021-9681(79)90119-X 10.1016/j.jdermsci.2007.05.018 10.1038/oby.2008.612 10.1038/sj.cdd.4400505 10.1006/bbrc.1996.0587 10.1186/1471-2091-9-S1-S6 10.1079/PHN2003585 10.1074/jbc.M301032200 10.1073/pnas.0337434100 10.1126/science.1141634 10.1073/pnas.0137044100 10.2337/diacare.19.6.629 10.1161/01.CIR.67.5.968 10.1016/j.metabol.2009.05.020 10.2152/jmi.53.218 10.1038/43185 |
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| References_xml | – reference: NakanoTShinkaTSeiMSatoYUmenoMSakamotoKNomuraINakahoriYJ. Med. Investig.20065321822210.2152/jmi.53.218 – reference: FleuryCNeverovaMCollinsSRaimbaultSChampignyOLevi-MeyrueisCBouillaudFSeldinMFSurwitRSRicquierDWardenCHNat. Genet.19971522322410.1038/ng0397-269 – reference: FraylingTMTimpsonNJWeedonMNZegginiEFreathyRMLindgrenCMPerryJRElliottKSLangoHRaynerNWShieldsBHarriesLWBarrettJCEllardSGrovesCJKnightBPatchAMNessAREbrahimSLawlorDARingSMBen-ShlomoYJarvelinMRSovioUBennettAJMelzerDFerrucciLLoosRJBarrosoIWarehamNJKarpeFOwenKRCardonLRWalkerMHitmanGAPalmerCNDoneyASMorrisADSmithGDHattersleyATMcCarthyMIScience20073168898941:CAS:528:DC%2BD2sXltVentL0%3D10.1126/science.114163417434869 – reference: SakamotoKSatoYShinkaTSeiMNomuraIUmenoMEwisAANakahoriYObesity200917104410491:CAS:528:DC%2BD1MXkvFKit70%3D10.1038/oby.2008.61219165168 – reference: KimWSParkBSSungJHYangJMParkSBKwakSJParkJSJ. Dermatol. 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| Snippet | We have previously reported that 26S proteasome subunit mRNA expressions correlate with male body mass index (BMI). In this study, to investigate whether... |
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| SubjectTerms | Adipocytes - cytology Adipocytes - drug effects Adipocytes - metabolism Adipogenesis - drug effects Adipogenesis - physiology Adult Asian Continental Ancestry Group Body Mass Index Cell Differentiation - drug effects Cell Differentiation - physiology Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Cysteine Proteinase Inhibitors - pharmacology Diabetes Endocrinology Humanities and Social Sciences Humans Internal Medicine Leupeptins - pharmacology Male Medicine Medicine & Public Health multidisciplinary Obesity - metabolism Obesity - physiopathology Original Article Proteasome Endopeptidase Complex - blood Proteasome Inhibitors Science Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism |
| Title | Proteasome activity correlates with male BMI and contributes to the differentiation of adipocyte in hADSC |
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