A new model of human lymphopoiesis across development and aging

• Published in: Trends in immunology Vol. 45; no. 7; pp. 495 - 510
• Main Authors: Alhaj Hussen, Kutaiba, Louis, Valentine, Canque, Bruno
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2024
• Subjects: age-related changes in lymphocyte production patterns; Aging - immunology; Animals; B-Lymphocytes - immunology; Cell Differentiation; cell-intrinsic versus extrinsic regulation; early lymphoid progenitors; human lymphopoiesis; Humans; Killer Cells, Natural - immunology; lymphoid development architecture; lymphoid differentiation trajectories; Lymphoid Progenitor Cells - cytology; Lymphoid Progenitor Cells - immunology; Lymphoid Progenitor Cells - metabolism; Lymphopoiesis; multi-lymphoid progenitors; thymus colonization; lymphoid development architecture; cell-intrinsic versus extrinsic regulation; thymus colonization; age-related changes in lymphocyte production patterns; early lymphoid progenitors; lymphoid differentiation trajectories; human lymphopoiesis; multi-lymphoid progenitors

We propose a model of human lymphopoiesis of bipartite organization stemming from founder populations of CD127/interleukin (IL)7R– or CD127/IL7R+ early lymphoid progenitors (ELPs) polarized toward the T-natural killer (NK)/innate lymphoid cell (ILC) or B lineages, respectively.CD127/IL7R– and CD127/...