Experimental heat pain for detecting pregnancy-induced analgesia in humans
Animal studies suggest that increased circulating estrogen and progesterone, and activation of the endorphin system cause prenancy-induced antinociceptive effects. Human studies have provided inconsistent results and have often lacked a nonpregnant control group. In this study, we compared sensitivi...
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| Published in | Anesthesia and analgesia Vol. 103; no. 5; pp. 1283 - 1287 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hagerstown, MD
Lippincott
01.11.2006
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| Subjects | |
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| Abstract | Animal studies suggest that increased circulating estrogen and progesterone, and activation of the endorphin system cause prenancy-induced antinociceptive effects. Human studies have provided inconsistent results and have often lacked a nonpregnant control group. In this study, we compared sensitivity to experimental heat and cold pain in pregnant and nonpregnant women. Nineteen healthy nonpregnant female volunteers and 20 pregnant women at term were enrolled. Pain threshold and tolerance were examined using experimental heat-induced pain and cold pressor pain models. Subjects were evaluated pre- and 1-2 days post-delivery (pregnant), or on consecutive days (nonpregnant). Heat pain tolerance was significantly increased in the pregnant women during pre and postdelivery when compared with nonpregnant controls (50.0 +/- 1.0 vs 49.0 +/- 1.2 and 50.1 +/- 0.7 vs 49.2 +/- 1.2 degrees C; mean +/- sd). However, pain induced by the cold pressor test was endured for a similar amount of time by both study groups. Pregnancy-induced analgesic effects at term can be detected in a model of experimental heat pain. These effects persist during the first 24-48 h after delivery. Experimental heat pain is a suitable modality for further characterizing the phenomenon of pregnancy-induced analgesia in humans. |
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| AbstractList | Animal studies suggest that increased circulating estrogen and progesterone, and activation of the endorphin system cause prenancy-induced antinociceptive effects. Human studies have provided inconsistent results and have often lacked a nonpregnant control group. In this study, we compared sensitivity to experimental heat and cold pain in pregnant and nonpregnant women. Nineteen healthy nonpregnant female volunteers and 20 pregnant women at term were enrolled. Pain threshold and tolerance were examined using experimental heat-induced pain and cold pressor pain models. Subjects were evaluated pre- and 1-2 days post-delivery (pregnant), or on consecutive days (nonpregnant). Heat pain tolerance was significantly increased in the pregnant women during pre and postdelivery when compared with nonpregnant controls (50.0 +/- 1.0 vs 49.0 +/- 1.2 and 50.1 +/- 0.7 vs 49.2 +/- 1.2 degrees C; mean +/- sd). However, pain induced by the cold pressor test was endured for a similar amount of time by both study groups. Pregnancy-induced analgesic effects at term can be detected in a model of experimental heat pain. These effects persist during the first 24-48 h after delivery. Experimental heat pain is a suitable modality for further characterizing the phenomenon of pregnancy-induced analgesia in humans. |
| Author | MATHUSAMY, Anbu D ANGST, Martin S LIN, Eric CARVALHO, Brendan RILEY, Edward T FULLER, Andrea J |
| Author_xml | – sequence: 1 givenname: Brendan surname: CARVALHO fullname: CARVALHO, Brendan organization: Department of Anesthesia, Stanford University School of Medicine, Stanford, Californi, United States – sequence: 2 givenname: Martin S surname: ANGST fullname: ANGST, Martin S organization: Department of Anesthesia, Stanford University School of Medicine, Stanford, Californi, United States – sequence: 3 givenname: Andrea J surname: FULLER fullname: FULLER, Andrea J organization: Northern Colorado Anesthesia Professional Consultants, Fort Collins, Colorado, United States – sequence: 4 givenname: Eric surname: LIN fullname: LIN, Eric organization: University of California San Francisco, San Francisco, California, United States – sequence: 5 givenname: Anbu D surname: MATHUSAMY fullname: MATHUSAMY, Anbu D organization: Bronx-Lebanon Hospital, Bronx, New York, United States – sequence: 6 givenname: Edward T surname: RILEY fullname: RILEY, Edward T organization: Department of Anesthesia, Stanford University School of Medicine, Stanford, Californi, United States |
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| References | Whipple (R13-38-20210902) 1990; 27 Sycha (R18-38-20210902) 2003; 56 Dawson-Basoa (R6-38-20210902) 1998; 794 Angst (R14-38-20210902) 2000; 92 Jayaram (R4-38-20210902) 1993; 76 Jarvis (R2-38-20210902) 1997; 72 Saisto (R12-38-20210902) 2001; 93 Jensen (R15-38-20210902) 1994; 58 Edwards (R19-38-20210902) 2003; 101 Dunbar (R10-38-20210902) 1988; 35 Shapira (R8-38-20210902) 1995; 12 Cogan (R7-38-20210902) 1986; 27 Jones (R17-38-20210902) 1988; 34 Hapidou (R20-38-20210902) 1992; 48 Goolkasian (R11-38-20210902) 1984; 20 Dawson-Basoa (R5-38-20210902) 1993; 601 Sander (R3-38-20210902) 1987; 408 Breivik (R16-38-20210902) 2000; 16 Sengupta (R9-38-20210902) 1984; 39 Gintzler (R1-38-20210902) 1980; 210 |
| References_xml | – volume: 76 start-page: 745 year: 1993 ident: R4-38-20210902 article-title: Progesterone-mediated potentiation of spinal sufentanil in rats. publication-title: Anesth Analg doi: 10.1213/00000539-199304000-00010 contributor: fullname: Jayaram – volume: 39 start-page: 982 year: 1984 ident: R9-38-20210902 article-title: The effect of labour and epidural analgesia on pain threshold. publication-title: Anaesthesia doi: 10.1111/j.1365-2044.1984.tb08886.x contributor: fullname: Sengupta – volume: 48 start-page: 177 year: 1992 ident: R20-38-20210902 article-title: Responsiveness to laboratory pain in women as a function of age and childbirth pain experience. publication-title: Pain doi: 10.1016/0304-3959(92)90056-H contributor: fullname: Hapidou – volume: 16 start-page: 22 year: 2000 ident: R16-38-20210902 article-title: A comparison of pain rating scales by sampling from clinical trial data. publication-title: Clin J Pain doi: 10.1097/00002508-200003000-00005 contributor: fullname: Breivik – volume: 72 start-page: 153 year: 1997 ident: R2-38-20210902 article-title: Opioid-mediated changes in nociceptive threshold during pregnancy and parturition in the sow. publication-title: Pain doi: 10.1016/S0304-3959(97)00027-4 contributor: fullname: Jarvis – volume: 27 start-page: 63 year: 1986 ident: R7-38-20210902 article-title: Pain and discomfort thresholds in late pregnancy. publication-title: Pain doi: 10.1016/0304-3959(86)90223-X contributor: fullname: Cogan – volume: 35 start-page: 265 year: 1988 ident: R10-38-20210902 article-title: An assessment of pain responses to thermal stimuli during stages of pregnancy. publication-title: Pain doi: 10.1016/0304-3959(88)90136-4 contributor: fullname: Dunbar – volume: 34 start-page: 117 year: 1988 ident: R17-38-20210902 article-title: Morphine and ibuprofen compared using the cold pressor test. publication-title: Pain doi: 10.1016/0304-3959(88)90156-X contributor: fullname: Jones – volume: 93 start-page: 123 year: 2001 ident: R12-38-20210902 article-title: Reduced pain tolerance during and after pregnancy in women suffering from fear of labor. publication-title: Pain doi: 10.1016/S0304-3959(01)00302-5 contributor: fullname: Saisto – volume: 12 start-page: 495 year: 1995 ident: R8-38-20210902 article-title: Assessment of pain threshold and pain tolerance in women in labour and in the early post-partum period by pressure algometry. publication-title: Eur J Anaesthesiol contributor: fullname: Shapira – volume: 210 start-page: 193 year: 1980 ident: R1-38-20210902 article-title: Endorphin-mediated increases in pain threshold during pregnancy. publication-title: Science doi: 10.1126/science.7414330 contributor: fullname: Gintzler – volume: 101 start-page: 155 year: 2003 ident: R19-38-20210902 article-title: Age-related differences in endogenous pain modulation: a comparison of diffuse noxious inhibitory controls in healthy older and younger adults. publication-title: Pain doi: 10.1016/S0304-3959(02)00324-X contributor: fullname: Edwards – volume: 408 start-page: 389 year: 1987 ident: R3-38-20210902 article-title: Spinal cord mediation of the opioid analgesia of pregnancy. publication-title: Brain Res doi: 10.1016/0006-8993(87)90412-4 contributor: fullname: Sander – volume: 27 start-page: 213 year: 1990 ident: R13-38-20210902 article-title: Sensory thresholds during the antepartum, intrapartum and postpartum periods. publication-title: Int J Nurs Stud doi: 10.1016/0020-7489(90)90036-I contributor: fullname: Whipple – volume: 58 start-page: 387 year: 1994 ident: R15-38-20210902 article-title: What is the maximum number of levels needed in pain intensity measurement? publication-title: Pain doi: 10.1016/0304-3959(94)90133-3 contributor: fullname: Jensen – volume: 20 start-page: 87 year: 1984 ident: R11-38-20210902 article-title: Pain reactions in pregnant women. publication-title: Pain doi: 10.1016/0304-3959(84)90814-5 contributor: fullname: Goolkasian – volume: 56 start-page: 165 year: 2003 ident: R18-38-20210902 article-title: A simple pain model for the evaluation of analgesic effects of NSAIDs in healthy subjects. publication-title: Br J Clin Pharmacol doi: 10.1046/j.0306-5251.2003.01869.x contributor: fullname: Sycha – volume: 601 start-page: 241 year: 1993 ident: R5-38-20210902 article-title: 17-β-estradiol and progesterone modulate an intrinsic opioid analgesic system. publication-title: Brain Res doi: 10.1016/0006-8993(93)91716-6 contributor: fullname: Dawson-Basoa – volume: 92 start-page: 312 year: 2000 ident: R14-38-20210902 article-title: Lumbar epidural morphine in humans and supraspinal analgesia to experimental heat pain. publication-title: Anesthesiology doi: 10.1097/00000542-200002000-00011 contributor: fullname: Angst – volume: 794 start-page: 61 year: 1998 ident: R6-38-20210902 article-title: Gestational and ovarian sex steroid antinociception: synergy between spinal κ and δ opioid systems. publication-title: Brain Res doi: 10.1016/S0006-8993(98)00192-9 contributor: fullname: Dawson-Basoa |
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| SubjectTerms | Adult Analgesia - methods Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Cold Temperature - adverse effects Female Hot Temperature - adverse effects Humans Medical sciences Pain - physiopathology Pain - prevention & control Pain Measurement - methods Pregnancy - physiology Prospective Studies |
| Title | Experimental heat pain for detecting pregnancy-induced analgesia in humans |
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