Chemotherapy-Induced IL8 Upregulates MDR1/ABCB1 in Tumor Blood Vessels and Results in Unfavorable Outcome

• Published in: Cancer research (Chicago, Ill.) Vol. 80; no. 14; pp. 2996 - 3008
• Main Authors: Kikuchi, Hiroshi, Maishi, Nako, Annan, Dorcas A., Alam, Mohammad Towfik, Dawood, Randa Ibrahim Hassan, Sato, Masumi, Morimoto, Masahiro, Takeda, Ryo, Ishizuka, Keita, Matsumoto, Ryuji, Akino, Tomoshige, Tsuchiya, Kunihiko, Abe, Takashige, Osawa, Takahiro, Miyajima, Naoto, Maruyama, Satoru, Harabayashi, Toru, Azuma, Manabu, Yamashiro, Katsushige, Ameda, Kaname, Kashiwagi, Akira, Matsuno, Yoshihiro, Hida, Yasuhiro, Shinohara, Nobuo, Hida, Kyoko
• Format: Journal Article
• Language: English
• Published: 15.07.2020

Abstract Tumor endothelial cells (TEC) lining tumor blood vessels actively contribute to tumor progression and metastasis. In addition to tumor cells, TEC may develop drug resistance during cancer treatment, allowing the tumor cells to survive chemotherapy and metastasize. We previously reported tha...