Association of combined genetic variations in SOD3, GPX3, PON1, and GSTT1 with hypertension and severity of coronary artery disease

• Published in: Heart and vessels Vol. 35; no. 7; pp. 918 - 929
• Main Authors: Decharatchakul, Nisa, Settasatian, Chatri, Settasatian, Nongnuch, Komanasin, Nantarat, Kukongviriyapan, Upa, Intharapetch, Pongsak, Senthong, Vichai, Sawanyawisuth, Kittisak
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.07.2020; Springer Nature B.V
• Subjects: Adult; Age; Aged; Aged, 80 and over; Antioxidants; Arteriosclerosis; Aryldialkylphosphatase - genetics; Atherosclerosis; Biomedical Engineering and Bioengineering; Cardiac Surgery; Cardiology; Cardiovascular disease; Coronary artery; Coronary artery disease; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - epidemiology; Coronary Artery Disease - genetics; Coronary vessels; Deoxyribonucleic acid; DNA; Female; Genetic Association Studies; Genetic diversity; Genetic Predisposition to Disease; Genotypes; Glutathione; Glutathione peroxidase; Glutathione Peroxidase - genetics; Glutathione transferase; Glutathione Transferase - genetics; GSTT1 protein; Heart Disease Risk Factors; Heart diseases; Humans; Hypertension; Hypertension - diagnosis; Hypertension - epidemiology; Hypertension - genetics; Incidence; Lipid Peroxidation - genetics; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Oxidative stress; Oxidative Stress - genetics; Paraoxonase; Paraoxonase 1; Pathogenesis; Peroxidase; Phenotype; Polymerase chain reaction; Polymorphism, Genetic; Population studies; Retrospective Studies; Risk Assessment; Severity of Illness Index; Superoxide dismutase; Superoxide Dismutase - genetics; Thailand - epidemiology; Vascular Surgery; Thailand; Glutathione peroxidase; Oxidative stress; Superoxide dismutase; Paraoxonase; transferase; Genetic risk score; Glutathione; Glutathione S-transferase

Oxidative stress plays a critical role in the pathophysiology of hypertension (HT) and the progression of atherosclerotic coronary artery disease (CAD). Genetic variations in superoxide dismutase ( SOD ), glutathione peroxidase 3 ( GPX3 ), paraoxonase 1 ( PON1 ) and glutathione S -transferase theta...