Specific molecular interaction sites on factor VII involved in factor X activation

• Published in: European journal of biochemistry Vol. 217; no. 2; pp. 509 - 518
• Main Authors: KUMAR, Anuradha, FAIR, Daryl S.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 15.10.1993; Blackwell
• Subjects: Amino Acid Sequence; Binding Sites; Biological and medical sciences; Blood coagulation. Blood cells; Cell Line; Coagulation factors; Factor VII - chemistry; Factor VII - isolation & purification; Factor VII - metabolism; Factor X - chemistry; Factor X - isolation & purification; Factor X - metabolism; Fundamental and applied biological sciences. Psychology; Humans; Molecular and cellular biology; Molecular Sequence Data; Peptide Fragments - chemistry; Peptide Fragments - metabolism; Thromboplastin - metabolism; Tumor Cells, Cultured; Human; Factor X; Carcinoma; Urinary bladder; Established cell line; Metabolic activation; Molecular interaction; Tumor; Coagulation factor; Factor VII

Factor VII, a serine‐protease zymogen, and tissue factor, the cellular receptor/coenzyme, are the protein components of the macromolecular complex which initiates the extrinsic pathway of the coagulation cascade. Previous studies were directed to the identification of functional sites on factor VII...