Loss of heterozygosity for chromosome 14q in neuroblastoma

• Published in: Medical and pediatric oncology Vol. 36; no. 1; p. 28
• Main Authors: Thompson, P M, Seifried, B A, Kyemba, S K, Jensen, S J, Guo, C, Maris, J M, Brodeur, G M, Stram, D O, Seeger, R C, Gerbing, R, Matthay, K K, Matise, T C, White, P S
• Format: Journal Article
• Language: English
• Published: United States 01.01.2001
• Subjects: Child; Child, Preschool; Chromosome Mapping; Chromosomes, Human, Pair 11 - genetics; Chromosomes, Human, Pair 11 - ultrastructure; Chromosomes, Human, Pair 14 - genetics; Chromosomes, Human, Pair 14 - ultrastructure; Cohort Studies; Disease-Free Survival; DNA, Neoplasm - genetics; Humans; Infant; Loss of Heterozygosity; Microsatellite Repeats; Neuroblastoma - genetics; Neuroblastoma - mortality; Neuroblastoma - pathology; Prognosis; Risk; Survival Analysis

Neuroblastoma is a genetically heterogeneous disease, with subsets of tumors demonstrating rearrangements of several genomic regions. Preliminary studies from several groups have identified loss of heterozygosity (LOH) for the long arm of chromosome 14 (14q) in 20-25% of primary neuroblastomas. To d...