Free Cortisol Mediates Associations of Maternal Urinary Heavy Metals with Neonatal Anthropometric Measures: A Cross-Sectional Study

• Published in: Toxics (Basel) Vol. 10; no. 4; p. 167
• Main Authors: Choi, Sohyeon, Lee, Aram, Choi, Gyuyeon, Moon, Hyo-Bang, Kim, Sungkyoon, Choi, Kyungho, Park, Jeongim
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.03.2022; MDPI
• Subjects: 8-OHdG; Biomarkers; Birth weight; Cadmium; Cortisol; Creatinine; Cross-sectional studies; Demographics; Density; Deoxyguanosine; DNA damage; Exposure; free cortisol; Gestational age; Heavy metals; Hormones; Immunoassay; Lead; Mercury; Mercury (metal); Neonates; Oxidative stress; Ponderal index; Pregnancy; Premature birth; Prenatal experience; Seafood; Statistical models; Urine; United States > US; Japan; mediation effect; mercury; Ponderal index; cadmium; lead; 8-OHdG; free cortisol

Prenatal exposure to heavy metals is known to be associated with adverse birth outcomes and oxidative stress biomarkers. In this study, we examined whether maternal free cortisol or 8-Hydroxy-2-Deoxyguanosine (8-OHdG) could mediate associations between maternal heavy metal exposure and birth outcome...