Cyclooxygenase-2 and Platelet-Derived Growth Factor Receptors as Potential Targets in Treating Aggressive Fibromatosis

• Published in: Clinical cancer research Vol. 13; no. 17; pp. 5034 - 5040
• Main Authors: SIGNORONI, Stefano, FRATTINI, Milo, GRONCHI, Alessandro, BERTARIO, Lucio, PIEROTTI, Marco A, PILOTTI, Silvana, NEGRI, Tiziana, PASTORE, Elisa, TAMBORINI, Elena, CASIERI, Paola, ORSENIGO, Marta, DA RIVA, Luca, RADICE, Paolo, SALA, Paola
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.09.2007
• Subjects: Adolescent; Adult; Aggressive Fibromatosis; Antineoplastic agents; beta Catenin - genetics; Biological and medical sciences; COX-2; Cyclooxygenase 2 - analysis; Cyclooxygenase 2 - physiology; Cyclooxygenase 2 Inhibitors - therapeutic use; Female; Fibromatosis, Aggressive - drug therapy; Fibromatosis, Aggressive - genetics; Fibromatosis, Aggressive - metabolism; Genes, APC; Humans; Immunohistochemistry; Male; Medical sciences; Middle Aged; Mutation; PDGFRA; PDGFRB; Pharmacology. Drug treatments; Polymerase Chain Reaction; Receptors, Platelet-Derived Growth Factor - analysis; Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors; Receptors, Platelet-Derived Growth Factor - genetics; RNA, Messenger - analysis; RTK activation profile; Target; Treatment; Targeting; Platelet derived growth factor receptor; Enzyme; Cyclooxygenase 2; Oxidoreductases; Benign neoplasm; Desmoid tumor

Purpose: To explore the molecular bases of potential new pharmacologic targets in aggressive fibromatosis (desmoid tumor). Experimental Design: Tumor specimens from 14 patients surgically treated for aggressive fibromatosis (6 familial adenomatous polyposis and 8 sporadic cases), analyzed for adenom...