The Transient Mechanics of Muscle Require Only a Single Force-Producing Cross-Bridge State and a 100 Å Working Stroke

• Published in: Biology (Basel, Switzerland) Vol. 9; no. 12; p. 475
• Main Authors: Knupp, Carlo, Squire, John M
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.12.2020; MDPI
• Subjects: Actin; Binding sites; isotonic shortening; length steps; Mechanics; muscle transients; Myosin; myosin cross-bridge cycle; Probability; Tetanus; myosin cross-bridge cycle; muscle transients; length steps; isotonic shortening

An informative probe of myosin cross-bridge behaviour in active muscle is a mechanical transient experiment where, for example, a fully active muscle initially held at constant length is suddenly shortened to a new fixed length, providing a force transient, or has its load suddenly reduced, providin...