A Transmissible Gastroenteritis Coronavirus Nucleoprotein Epitope Elicits T Helper Cells That Collaborate in the in Vitro Antibody Synthesis to the Three Major Structural Viral Proteins
Four strong T cell epitopes have been identified studying the blastogenic response of lymphocytes from haplotype-defined transmissible gastroenteritis virus (TGEV) immune miniswine to sixty-one 15-mer synthetic peptides. Three of these epitopes are located on the nucleoprotein (N48 amino acids 46 to...
Saved in:
| Published in | Virology (New York, N.Y.) Vol. 212; no. 2; pp. 746 - 751 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.10.1995
Academic Press |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Four strong T cell epitopes have been identified studying the blastogenic response of lymphocytes from haplotype-defined transmissible gastroenteritis virus (TGEV) immune miniswine to sixty-one 15-mer synthetic peptides. Three of these epitopes are located on the nucleoprotein (N48 amino acids 46 to 60; N272, amino acids 272 to 286; and N321 amino acid 321 to 335), and one on the membrane protein (M196, amino acids 196 to 210). N321, peptide induced the highest T cell response and was recognized by immune miniswine lymphocytes with haplotypes dd, aa , and cc. T lymphocytes from peptide N321-immune miniswine reconstituted the in vitro synthesis of TGEV-specific antibodies by complementing CD4- TGEV-immune cells. This response was directed at least against the three major structural proteins. The synthesized antibodies specific for S protein preferentially recognized discontinous epitopes and neutralized TGEV infectivity. These results show that peptide N321 defines a functional T helper epitope eliciting T cells capable of collaborating with B cells specific for different proteins of TGEV. |
|---|---|
| AbstractList | Four strong T cell epitopes have been identified studying the blastogenic response of lymphocytes from haplotype-defined transmissible gastroenteritis virus (TGEV) immune miniswine to sixty-one 15-mer synthetic peptides. Three of these epitopes are located on the nucleoprotein (N48 amino acids 46 to 60; N272, amino acids 272 to 286; and N321 amino acid 321 to 335), and one on the membrane protein (M196, amino acids 196 to 210). N321, peptide induced the highest T cell response and was recognized by immune miniswine lymphocytes with haplotypes dd, aa , and cc. T lymphocytes from peptide N321-immune miniswine reconstituted the in vitro synthesis of TGEV-specific antibodies by complementing CD4- TGEV-immune cells. This response was directed at least against the three major structural proteins. The synthesized antibodies specific for S protein preferentially recognized discontinous epitopes and neutralized TGEV infectivity. These results show that peptide N321 defines a functional T helper epitope eliciting T cells capable of collaborating with B cells specific for different proteins of TGEV. Four strong T cell epitopes have been identified studying the blastogenic response of lymphocytes from haplotype-defined transmissible gastroenteritis virus (TGEV) immune miniswine to sixty-one 15-mer synthetic peptides. Three of these epitopes are located on the nucleoprotein (N sub(46), amino acids 46 to 60; N sub(272), amino acids 272 to 286; and N sub(321), amino acids 321 to 335), and one on the membrane protein (M sub(196), amino acids 196 to 210). N sub(321) peptide induced the highest T cell response and was recognized by immune miniswine lymphocytes with haplotypes dd, aa, and cc. T lymphocytes from peptide N sub(321)-immune miniswine reconstituted the in vitro synthesis of TGEV-specific antibodies by complementing CD4 super(-) TGEV-immune cells. This response was directed at least against the three major structural proteins. The synthesized antibodies specific for S protein preferentially recognized discontinous epitopes and neutralized TGEV infectivity. These results show that peptide N sub(321) defines a functional T helper epitope eliciting T cells capable of collaborating with B cells specific for different proteins of TGEV. Four strong T cell epitopes have been identified studying the blastogenic response of lymphocytes from haplotype-defined transmissible gastroenteritis virus (TGEV) immune miniswine to sixty-one 15-mer synthetic peptides. Three of these epitopes are located on the nucleoprotein (N 48 amino acids 46 to 60; N 272 , amino acids 272 to 286; and N 321 amino acid 321 to 335), and one on the membrane protein (M 196 , amino acids 196 to 210). N 321 , peptide induced the highest T cell response and was recognized by immune miniswine lymphocytes with haplotypes dd , aa , and cc . T lymphocytes from peptide N 321 -immune miniswine reconstituted the in vitro synthesis of TGEV-specific antibodies by complementing CD4 - TGEV-immune cells. This response was directed at least against the three major structural proteins. The synthesized antibodies specific for S protein preferentially recognized discontinous epitopes and neutralized TGEV infectivity. These results show that peptide N 321 defines a functional T helper epitope eliciting T cells capable of collaborating with B cells specific for different proteins of TGEV. Four strong T cell epitopes have been identified studying the blastogenic response of lymphocytes from haplotype-defined transmissible gastroenteritis virus (TGEV) immune miniswine to sixty-one 15-mer synthetic peptides. Three of these epitopes are located on the nucleoprotein (N46, amino acids 46 to 60; N272, amino acids 272 to 286; and N321, amino acids 321 to 335), and one on the membrane protein (M196, amino acids 196 to 210). N321 peptide induced the highest T cell response and was recognized by immune miniswine lymphocytes with haplotypes dd, aa, and cc. T lymphocytes from peptide N321-immune miniswine reconstituted the in vitro synthesis of TGEV-specific antibodies by complementing CD4- TGEV-immune cells. This response was directed at least against the three major structural proteins. The synthesized antibodies specific for S protein preferentially recognized discontinuous epitopes and neutralized TGEV infectivity. These results show that peptide N321 defines a functional T helper epitope eliciting T cells capable of collaborating with B cells specific for different proteins of TGEV. Four strong T cell epitopes have been identified studying the blastogenic response of lymphocytes from haplotype-defined transmissible gastroenteritis virus (TGEV) immune miniswine to sixty-one 15-mer synthetic peptides. Three of these epitopes are located on the nucleoprotein (N46, amino acids 46 to 60; N272, amino acids 272 to 286; and N321, amino acids 321 to 335), and one on the membrane protein (M196, amino acids 196 to 210). N321 peptide induced the highest T cell response and was recognized by immune miniswine lymphocytes with haplotypes dd, aa, and cc. T lymphocytes from peptide N321-immune miniswine reconstituted the in vitro synthesis of TGEV-specific antibodies by complementing CD4- TGEV-immune cells. This response was directed at least against the three major structural proteins. The synthesized antibodies specific for S protein preferentially recognized discontinuous epitopes and neutralized TGEV infectivity. These results show that peptide N321 defines a functional T helper epitope eliciting T cells capable of collaborating with B cells specific for different proteins of TGEV |
| Author | Antón, Inés M. Meloen, Rob H. Enjuanes, Luis Suñé, Carlos Borrás-Cuesta, Francisco |
| Author_xml | – sequence: 1 givenname: Inés M. surname: Antón fullname: Antón, Inés M. – sequence: 2 givenname: Carlos surname: Suñé fullname: Suñé, Carlos – sequence: 3 givenname: Rob H. surname: Meloen fullname: Meloen, Rob H. – sequence: 4 givenname: Francisco surname: Borrás-Cuesta fullname: Borrás-Cuesta, Francisco – sequence: 5 givenname: Luis surname: Enjuanes fullname: Enjuanes, Luis |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/7571447$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFUkFr2zAYFaOjS7tddxgMdOrNmWTZkn0ZhJC1g3YbJN1VyPLnRsWRPEkO5Kft301uQlkPYxcJ8d73ve97ehfozDoLCL2nZE4J4Z_2xrs5retyTktWvkIzSmqeEVbQMzQjpMgzXuX5G3QRwiNJbyHIOToXpaBFIWbo9wJvvLJhZ0IwTQ_4WoXoHdgI3kQT8NJ5Z1VSGQP-Nuoe3OBdBGPxajDRDYBXvdEmBrzBN9AP4PES-j49tyqm6r5XjfMqAk4lcft0_TRJAi9sNI1rD3h9sAkISSy6J8pm6wHwnXp0Hq-jH3UcvepT2XT-OMqHt-h1p_oA7073Jbr_stosb7Lb79dfl4vbTLPkSqZFp7jmuqm6QtVN21FdpN0r0UDBBaeUgyjLtq0pF3nDuoa1XBCqhWpZTlvBLtHnY99hbHbQ6mRNGkMO3uyUP0injHyJWLOVD24vBWWUlUVqcHVq4N2vEUKUyWydPFIW3BikEGWRvo7_l0h5VVPBSCLOj0TtXQgeuudpKJFTKuSUCjmlQk6pSAUf_97hmX6KQcI_HPFOOakevAnyfl1zUuVsmr86gpBc3hvwMmgDVkNrPOgoW2f-pfsHwcHWUg |
| CitedBy_id | crossref_primary_10_1128_MMBR_69_4_635_664_2005 crossref_primary_10_1371_journal_pone_0163920 crossref_primary_10_1016_j_jviromet_2015_08_011 crossref_primary_10_1016_S0165_2427_99_00074_4 crossref_primary_10_1007_s00253_016_7424_9 crossref_primary_10_1016_S0168_1702_01_00333_1 crossref_primary_10_1128_JVI_72_5_3762_3772_1998 crossref_primary_10_1111_j_1348_0421_2010_00275_x crossref_primary_10_1128_JVI_02568_06 crossref_primary_10_1016_j_virusres_2007_01_021 crossref_primary_10_1038_nbt0498_349 crossref_primary_10_2460_ajvr_74_10_1353 crossref_primary_10_1111_j_1468_1331_1997_tb00318_x crossref_primary_10_1016_j_immuni_2020_07_005 crossref_primary_10_1006_expr_1998_4309 crossref_primary_10_1016_S0168_1656_99_00140_6 crossref_primary_10_1016_S0168_1702_96_01390_1 |
| ContentType | Journal Article |
| Copyright | 1995 Academic Press Copyright © 1995 Academic Press. All rights reserved. 1995 Academic Press |
| Copyright_xml | – notice: 1995 Academic Press – notice: Copyright © 1995 Academic Press. All rights reserved. 1995 Academic Press |
| DBID | 6I. AAFTH FBQ CGR CUY CVF ECM EIF NPM AAYXX CITATION 7T5 7U9 H94 7X8 5PM |
| DOI | 10.1006/viro.1995.1535 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access AGRIS Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Immunology Abstracts Virology and AIDS Abstracts AIDS and Cancer Research Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef AIDS and Cancer Research Abstracts Immunology Abstracts Virology and AIDS Abstracts MEDLINE - Academic |
| DatabaseTitleList | AIDS and Cancer Research Abstracts MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1096-0341 |
| EndPage | 751 |
| ExternalDocumentID | 10_1006_viro_1995_1535 7571447 US9608234 S0042682285715358 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M -DZ -~X .55 .GJ .~1 123 1B1 1RT 1~. 1~5 29Q 3O- 457 4G. 53G 5RE 5VS 6I. 7-5 8P~ 9JM AAAJQ AABNK AACTN AAEDT AAEDW AAFTH AAIAV AAIKJ AAKOC AAOAW AAQFI AAQXK AARKO AAXUO ABBQC ABEFU ABFNM ABFRF ABJNI ABLVK ABMAC ABVKL ABYKQ ACDAQ ACGFO ACGFS ACRLP ADBBV ADEZE ADFGL ADMUD AEFWE AEKER AENEX AEXQZ AFCTW AFFNX AFKWA AFMIJ AFTJW AFXIZ AGEKW AGUBO AGYEJ AHHHB AHPSJ AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CAG CJTIS COF CS3 DM4 DU5 EFBJH EFLBG EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-Q HMG HVGLF IHE IXB J1W KOM LCYCR LG5 LUGTX LZ5 M29 M41 MO0 MVM N9A NCXOZ O-L OAUVE OHT OK1 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SES SSH SSI SSZ T5K TN5 WH7 X7M XOL XPP Y6R ZGI ZU3 ~G- ~KM ABPTK AEQTP FBQ 0SF AALRI AAXKI ADVLN AKRWK CGR CUY CVF EBS ECM EIF NPM Q44 .1- .FO 0R~ 1P~ 4.4 71M AAYXX ABMZM ABXDB AEBSH AEVXI AFJKZ AFRHN AGHFR AJUYK CITATION EJD FA8 G-2 GBLVA HEJ HMK HMO HX~ HZ~ H~9 O9- OD- OO. OZT P-8 RIG SEW SIN UAP UQL WUQ Z5R ZKB ZMT 7T5 7U9 H94 7X8 5PM |
| ID | FETCH-LOGICAL-c3995-c7fa6c6cb8f4a9bdf1c471487be4676116e755dd91672b3fb3d6701c7ad321d73 |
| IEDL.DBID | IXB |
| ISSN | 0042-6822 |
| IngestDate | Tue Sep 17 21:08:09 EDT 2024 Fri Oct 25 11:35:24 EDT 2024 Fri Oct 25 01:22:54 EDT 2024 Thu Sep 26 17:08:30 EDT 2024 Wed Oct 16 00:46:13 EDT 2024 Wed Dec 27 19:15:38 EST 2023 Fri Feb 23 02:24:58 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | http://www.elsevier.com/open-access/userlicense/1.0 Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3995-c7fa6c6cb8f4a9bdf1c471487be4676116e755dd91672b3fb3d6701c7ad321d73 |
| Notes | 9608234 L73 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0042682285715358 |
| PMID | 7571447 |
| PQID | 16891730 |
| PQPubID | 23462 |
| PageCount | 6 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7131354 proquest_miscellaneous_77545356 proquest_miscellaneous_16891730 crossref_primary_10_1006_viro_1995_1535 pubmed_primary_7571447 fao_agris_US9608234 elsevier_sciencedirect_doi_10_1006_viro_1995_1535 |
| PublicationCentury | 1900 |
| PublicationDate | 1995-10-01 |
| PublicationDateYYYYMMDD | 1995-10-01 |
| PublicationDate_xml | – month: 10 year: 1995 text: 1995-10-01 day: 01 |
| PublicationDecade | 1990 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Virology (New York, N.Y.) |
| PublicationTitleAlternate | Virology |
| PublicationYear | 1995 |
| Publisher | Elsevier Inc Academic Press |
| Publisher_xml | – name: Elsevier Inc – name: Academic Press |
| SSID | ssj0004770 |
| Score | 1.6284316 |
| Snippet | Four strong T cell epitopes have been identified studying the blastogenic response of lymphocytes from haplotype-defined transmissible gastroenteritis virus... |
| SourceID | pubmedcentral proquest crossref pubmed fao elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 746 |
| SubjectTerms | Amino Acid Sequence Animals Antibodies, Viral - biosynthesis Antibody Formation Antibody Specificity ANTICORPS ANTICUERPOS ANTIGENE ANTIGENOS CERDO ENANO Epitopes, T-Lymphocyte - immunology EXPERIMENTACION IN VITRO EXPERIMENTATION IN VITRO Haplotypes LINFOCITOS LYMPHOCYTE Lymphocyte Activation Major Histocompatibility Complex Molecular Sequence Data NAIN Neutralization Tests NUCLEOPROTEINAS NUCLEOPROTEINE Peptides - chemical synthesis Peptides - immunology PODER PATOGENO PORCIN POUVOIR PATHOGENE PROTEINAS PROTEINE REACCION ANTIGENO-ANTICUERPO REACTION ANTIGENE ANTICORPS Short Communication Swine T-Lymphocytes, Helper-Inducer - immunology transmissible gastroenteritis virus Transmissible gastroenteritis virus - immunology Viral Structural Proteins - chemistry Viral Structural Proteins - immunology VIRUS GASTROENTERITE DU PORC VIRUS GASTROENTERITIS TRANSMISIBLE |
| Title | A Transmissible Gastroenteritis Coronavirus Nucleoprotein Epitope Elicits T Helper Cells That Collaborate in the in Vitro Antibody Synthesis to the Three Major Structural Viral Proteins |
| URI | https://dx.doi.org/10.1006/viro.1995.1535 https://www.ncbi.nlm.nih.gov/pubmed/7571447 https://search.proquest.com/docview/16891730 https://search.proquest.com/docview/77545356 https://pubmed.ncbi.nlm.nih.gov/PMC7131354 |
| Volume | 212 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Bb9MwFLa2ISQuEwwmyqD4gMQpa13HdnLsqo7CWIXUduotsmN7C6qSqskOvfC_-He8l7SFInrhEiu1Hbt9z-97Vv19IeQD94xLzkxgFLdBqG0aGGFFwCKve5bFxmvcKN6O5WgWfpmL-REZbLkweKxyE_ubmF5H680nnc2v2VlmGXJ8AV0A3yKhYNkKJPxyQGck8c2vfnMjldrRULD1VrixKztIJEO2nrjE_oeA6djr4l_p59-nKP-Apevn5HSTT9J-M-UX5MjlZ-Rp84bJ9Uvys09rNAJrgu8vHP2ky2pVoBBnrWZEB6hgoGGOjyUdo7ZxUSs3ZDkdLmGxLx0dLrI0q0o6pQBRS7eiA7dYwO2Druhg50WOQhdIJrG4y2AI2s-rzBR2TSfrHCpKGKwq6iZT8B9Hb_X3YkUntX4tan9AN7x-a4YvX5HZ9XA6GAWbtzUEKdJjg1R5LVOZmsiHOjbWsxSAD_ZDxkEwloxJp4SwFvJR1TPcG26l6rJUact7zCp-Tk7yInevCU2tNl4I57iJw9iouBsZq0Ptfcx6XtsW-bg1VbJsRDmSRn5ZJmjUBI2aoFFbhG0tmey5VQKIcbDPGZg80fcQZZPZBLZ4UY-HLfJ-6wIJ2Az_VtG5Kx7LhMkI9ry8e7gFqgzCg2WLnDcus5u1At8NQ9Uias-XdvUo_r1fk2cPtQi4YpxxEb75jy94QZ7VxPz6SOJbcgKGdu8gtapMmxxf_mBt8qR_dXfzFcvPN6Nxu15RvwDg8Sx1 |
| link.rule.ids | 230,315,783,787,888,3515,4511,24130,27583,27938,27939,45599,45677,45693,45888 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9MwGLb2IQQXBIOJMmA-IHEKrePYTo6l6iisrZDaTrtZdmxvQVVSNdmhP23_jtdJWiiiFy6JEn8mz-v3Q_H7BKGP1BHKKdGBFtQEkTJpoJlhAYmdCg1JtFM-UJxM-WgRfb9lt0dosM2F8dsqW93f6PRaW7d3uu3b7K6yzOf4gnUB-xYzAcuWxcfoFLwBARHYaf_LzfX4d3qkELtMFN9gy93Y412fS-YT9thn38Uh23TsVPEvD_TvjZR_WKarF-h561LifjPrl-jI5mfoSfOTyc0r9NjHtUECQEH8lxZ_VWW1LjwXZ01ohAeexEDBHB9KPPX0xkVN3pDleLiC9b6yeLjM0qwq8RyDlVrZNR7Y5RIu71WFBztBshiagD_pTzcZDIH7eZXpwmzwbJNDQQmDVUVdZQ4iZPFE_SzWeFZT2Hr6D2jmjz-a4cvXaHE1nA9GQfvDhiD1GbJBKpziKU917CKVaONICrYPQiJtQR9zQrgVjBkDLqkINXWaGi56JBXK0JAYQc_RSV7k9g3CqVHaMWYt1UmUaJH0Ym1UpJxLSOiU6aBPW6jkquHlkA0DM5ceVOlBlR7UDiJbJOWeZEkwGgfbnAHkUt2BopWLGUR5cUijDrrcioAEzPyXFZXb4qGUhMcQ9tLe4RqeaBA65h103ojMbtYCxDeKRAeJPVnalXv-7_2SPLuvecAFoYSy6O1_POAlejqaT8Zy_G16fYGe1Xn69Q7Fd-gEQLfvwdOq9Id2Jf0CtEMsng |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+transmissible+gastroenteritis+coronavirus+nucleoprotein+epitope+elicits+T+helper+cells+that+collaborate+in+the+in+vitro+antibody+synthesis+to+the+three+major+structural+viral+proteins&rft.jtitle=Virology+%28New+York%2C+N.Y.%29&rft.au=Anton%2C+I.M.+%28Universidad+Autonoma+de+Madrid%2C+Madrid%2C+Spain.%29&rft.au=Sune%2C+C&rft.au=Meloen%2C+R.H&rft.au=Borras-Cuesta%2C+F&rft.date=1995-10-01&rft.issn=0042-6822&rft.eissn=1096-0341&rft.volume=212&rft.issue=2&rft_id=info:doi/10.1006%2Fviro.1995.1535&rft.externalDocID=US9608234 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0042-6822&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0042-6822&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0042-6822&client=summon |