Bcl-xL is an oncogenic driver in colorectal cancer

• Published in: Cell death & disease Vol. 7; no. 8; p. e2342
• Main Authors: Scherr, Anna-Lena, Gdynia, Georg, Salou, Mariam, Radhakrishnan, Praveen, Duglova, Katarina, Heller, Anette, Keim, Sophia, Kautz, Nicole, Jassowicz, Adam, Elssner, Christin, He, You-Wen, Jaeger, Dirk, Heikenwalder, Mathias, Schneider, Martin, Weber, Achim, Roth, Wilfried, Schulze-Bergkamen, Henning, Koehler, Bruno Christian
• Format: Journal Article
• Language: English
• Published: England Springer Nature B.V 18.08.2016; Nature Publishing Group
• Subjects: Animals; Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; bcl-X Protein - genetics; bcl-X Protein - metabolism; Biphenyl Compounds - pharmacology; Carcinogenesis - drug effects; Carcinogenesis - genetics; Carcinogenesis - pathology; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation - drug effects; Colorectal cancer; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Disease Models, Animal; Enterocytes - drug effects; Enterocytes - metabolism; Gene Expression Regulation, Neoplastic - drug effects; Gene Knockdown Techniques; Humans; Inflammation - genetics; Inflammation - pathology; Lymphocytes, Tumor-Infiltrating - drug effects; Lymphocytes, Tumor-Infiltrating - metabolism; Mice; Mice, Knockout; Nitrophenols - pharmacology; Oncogenes; Organ Specificity; Original; Phenotype; Piperazines - pharmacology; Protein expression; Sulfonamides - pharmacology; Tumorigenesis; Up-Regulation - drug effects; Up-Regulation - genetics

Colorectal cancer (CRC) is the second most common malignant neoplasia in women and men worldwide. The B-cell lymphoma 2 (Bcl-2) protein family is mainly known for its pivotal role in the regulation of the mitochondrial death pathway. Anti-apoptotic Bcl-2 proteins may provide survival benefits and in...