Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans

• Published in: The FASEB journal Vol. 24; no. 8; pp. 2795 - 2803
• Main Authors: Waluk, Dominik P, Schultz, Niklas, Hunt, Mary C
• Format: Journal Article
• Language: English
• Published: United States The Federation of American Societies for Experimental Biology 01.08.2010
• Subjects: Acyl Coenzyme A - metabolism; Acyltransferases - genetics; Acyltransferases - metabolism; Glycine - analogs & derivatives; Glycine - biosynthesis; Humans; Lung - chemistry; RNA, Messenger - analysis; Skin - chemistry; Tissue Distribution

The discovery of glycine conjugates of long-chain fatty acids (N-acyl glycines) in the brain and other non-neuronal tissues has led to the identification of an emerging class of bioactive lipids. The biological activities of N-acyl glycines include antinociceptive, anti-inflammatory and antiprolifer...