Recovery of postischemic brain metabolism and function following treatment with a free radical scavenger and platelet-activating factor antagonists

• Published in: Journal of neurochemistry Vol. 56; no. 1; p. 311
• Main Authors: Gilboe, D D, Kintner, D, Fitzpatrick, J H, Emoto, S E, Esanu, A, Braquet, P G, Bazan, N G
• Format: Journal Article
• Language: English
• Published: England 01.01.1991
• Subjects: Adenosine Monophosphate - metabolism; Animals; Azepines - pharmacology; Brain - blood supply; Brain - drug effects; Brain - physiopathology; Creatine - metabolism; Dimethyl Sulfoxide - pharmacology; Dogs; Electroencephalography; Evoked Potentials, Auditory; Free Radical Scavengers; Glucose - metabolism; Glycogen - metabolism; Hydrogen-Ion Concentration; Ischemic Attack, Transient - physiopathology; Kinetics; Oxygen - metabolism; Phosphocreatine - metabolism; Platelet Activating Factor - antagonists & inhibitors; Thienopyridines; Triazoles - pharmacology; Vascular Resistance

We have studied the metabolic and functional effects of two new platelet-activating factor (PAF) antagonists (BN 50726 and BN 50739) and their diluent (dimethyl sulfoxide; DMSO) during reoxygenation of the 14-min ischemic isolated brain. Blood gases, EEG, auditory evoked potentials, cerebral metabol...