Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

• Published in: Acta neuropathologica Vol. 119; no. 6; pp. 689 - 702
• Main Authors: Beach, Thomas G., Adler, Charles H., Sue, Lucia I., Vedders, Linda, Lue, LihFen, White III, Charles L., Akiyama, Haru, Caviness, John N., Shill, Holly A., Sabbagh, Marwan N., Walker, Douglas G.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.06.2010
• Subjects: Aged; Aged, 80 and over; alpha-Synuclein - metabolism; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Brain - metabolism; Brain - pathology; Female; Ganglia, Sympathetic - metabolism; Ganglia, Sympathetic - pathology; Gastrointestinal Tract - metabolism; Gastrointestinal Tract - pathology; Humans; Immunohistochemistry; Lewy Body Disease - metabolism; Lewy Body Disease - pathology; Male; Medicine; Medicine & Public Health; Neurosciences; Original Paper; Parkinson Disease - metabolism; Parkinson Disease - pathology; Pathology; Peripheral Nervous System - metabolism; Peripheral Nervous System - pathology; Phosphorylation; Spinal Cord - metabolism; Spinal Cord - pathology; Peripheral nervous system; Heart; α-Synuclein; Stomach; Spinal cord; Alzheimer’s disease; Submandibular gland; Sympathetic nervous system; Esophagus; Parkinsonism; Enteric nervous system; Autonomic nervous system; Gastrointestinal system; Adrenal gland; Parkinson’s disease; Incidental Lewy bodies; Dementia with Lewy bodies

A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, including 23 normal elderly, 7 with incidental Lewy body disease (ILBD), 17 with Parkinson’s disease (PD), 9 with d...