Identification of human cytochrome P450 and UGT enzymes involved in the metabolism of ferulic acid, a major bioactive component in traditional Chinese medicines - ZHUANG, Xiao-Mei; CHEN, Lin; TAN, Yan; YANG, Hai-Ying; LU, Chuang; GAO, Yue; LI, Hua (Chinese journal of natural medicines, 2017)
Keywords: anti-allergic agents; antioxidant activity; bioactive compounds; biochemical pathways; chemical inhibitors; Coumaric Acids - chemistry; Coumaric Acids - metabolism; cytochrome P-450; Cytochrome P-450 Enzyme System - chemistry; Cytochrome P-450 Enzyme System - metabolism; drug interactions; Drugs, Chinese Herbal - metabolism; enzymes; Ferulic acid; Glucuronosyltransferase - chemistry; Glucuronosyltransferase - metabolism; hepatoprotective effect; Herb-drug interaction; herbal medicines; herbs; Human liver microsomes; Humans; Kinetics; liver microsomes; Medicine, Chinese Traditional; metabolism; Microsomes, Liver - chemistry; Microsomes, Liver - enzymology; NADP (coenzyme); Oriental traditional medicine; phenotype; Reaction phenotyping; risk; Human liver microsomes; Herb-drug interaction; Reaction phenotyping; Ferulic acid