Inferring causal effects of homocysteine and B-vitamin concentrations on bone mineral density and fractures: Mendelian randomization analyses

• Published in: Frontiers in endocrinology (Lausanne) Vol. 13; p. 1037546
• Main Authors: Fu, Liwan, Wang, Yuquan, Hu, Yue-Qing
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 28.11.2022
• Subjects: B vitamins; Bone Density - genetics; bone mineral density; Endocrinology; Female; fractures; Fractures, Bone - etiology; Fractures, Bone - genetics; Genome-Wide Association Study; Homocysteine; Humans; Male; Mendelian randomization; Mendelian Randomization Analysis; Middle Aged; Vitamin B 12; Vitamin B Complex; homocysteine; bone mineral density; Mendelian randomization; B vitamins; fractures

In the progress of bone metabolism, homocysteine (Hcy) and B vitamins play substantial roles. However, the causal associations of homocysteine, B-vitamin concentrations with bone mineral density (BMD), and fractures remain unclear. Therefore, we employed a two-sample Mendelian randomization (MR) des...