Synapse formation: from cellular and molecular mechanisms to neurodevelopmental and neurodegenerative disorders

• Published in: Journal of neurophysiology Vol. 121; no. 4; pp. 1381 - 1397
• Main Authors: Batool, Shadab, Raza, Hussain, Zaidi, Jawwad, Riaz, Saba, Hasan, Sean, Syed, Naweed I.
• Format: Journal Article
• Language: English
• Published: United States 01.04.2019
• Subjects: Animals; Humans; Neurodegenerative Diseases - etiology; Neurodevelopmental Disorders - etiology; Neurogenesis; Neuronal Plasticity; Synapses - pathology; Synapses - physiology; synaptic proteins; neuronal network; synaptic transmission; synaptic plasticity; growth cones; neurodevelopment and neurodegeneration; epigenetics; synapse formation

The precise patterns of neuronal assembly during development determine all functional outputs of a nervous system; these may range from simple reflexes to learning, memory, cognition, etc. To understand how brain functions and how best to repair it after injury, disease, or trauma, it is imperative...