Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells

• Published in: Cancers Vol. 13; no. 17; p. 4266
• Main Authors: Kung, Fang-Ping, Lim, Yun-Ping, Chao, Wen-Ying, Zhang, Yi-Sheng, Yu, Hui-I, Tai, Tsai-Sung, Lu, Chieh-Hsiang, Chen, Shu-Hsin, Li, Yi-Zhen, Zhao, Pei-Wen, Yen, Yu-Pei, Lee, Ying-Ray
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 24.08.2021; MDPI
• Subjects: AKT protein; Antitumor activity; Apoptosis; Caspase; Cell cycle; Cell growth; Cell proliferation; Cell viability; Malignancy; Mitochondria; Patients; Piper longum; Reactive oxygen species; Signal transduction; Thyroid cancer; TOR protein; Tumorigenesis; Tumors; Xenografts

Thyroid cancer (TC) is the most common endocrine malignancy, and its global incidence has steadily increased over the past 15 years. TC is broadly divided into well-differentiated, poorly differentiated, and undifferentiated types, depending on the histological and clinical parameters. Thus far, the...