Prenatal carbofuran exposure inhibits hippocampal neurogenesis and causes learning and memory deficits in offspring

• Published in: Toxicological sciences Vol. 127; no. 1; pp. 84 - 100
• Main Authors: Mishra, Divya, Tiwari, Shashi Kant, Agarwal, Swati, Sharma, Vinod Praveen, Chaturvedi, Rajnish Kumar
• Format: Journal Article
• Language: English
• Published: United States 01.05.2012
• Subjects: Animals; Apoptosis - drug effects; Carbofuran - toxicity; Cell Differentiation - drug effects; Cell Proliferation - drug effects; Cell Survival - drug effects; Down-Regulation - drug effects; Female; Gene Expression Regulation, Developmental - drug effects; Hippocampus - drug effects; Hippocampus - embryology; Hippocampus - physiology; Insecticides - toxicity; Learning Disorders - chemically induced; Learning Disorders - metabolism; Maternal Exposure; Memory Disorders - chemically induced; Memory Disorders - metabolism; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurons - drug effects; Neurons - pathology; Pregnancy; Prenatal Exposure Delayed Effects - chemically induced; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism

Neurogenesis is a process of generation of new neurons in the hippocampus and associated with learning and memory. Carbofuran, a carbamate pesticide, elicits several neurochemical, neurophysiological, and neurobehavioral deficits. We evaluated whether chronic prenatal oral exposure of carbofuran dur...