Fabrication of a bioadhesive transdermal device from chitosan and hyaluronic acid for the controlled release of lidocaine

• Published in: Carbohydrate polymers Vol. 152; pp. 687 - 698
• Main Authors: Anirudhan, T.S., Nair, Syam S., Nair, Anoop S.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 05.11.2016
• Subjects: adhesion; Bioadhesion; Butyl methacrylate; chitosan; drugs; Fourier transform infrared spectroscopy; humans; Hyaluronic acid; Lidocaine; mechanical properties; nuclear magnetic resonance spectroscopy; permeability; rats; scanning electron microscopy; skin irritation; storage time; Transdermal drug delivery; transmission electron microscopy; water vapor; X-ray diffraction; Transdermal drug delivery; Butyl methacrylate; Bioadhesion; Lidocaine; Hyaluronic acid

Schematic representation of A) fabrication of lidocaine loaded transdermal device, B) release of lidocaine from the device across stratum corneum. [Display omitted] •Synthesized and fabricated a novel transdermal film based device for the controlled release of lidocaine.•The device possess excellent...