Early cellular responses of germ-free and specific-pathogen-free mice to Francisella tularensis infection

• Published in: Microbial pathogenesis Vol. 123; pp. 314 - 322
• Main Authors: Krocova, Zuzana, Plzakova, Lenka, Benuchova, Milota, Macela, Ales, Kubelkova, Klara
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2018
• Subjects: animal models; Animals; atomization; bacteria; Bacterial Vaccines - immunology; Cellular response; Cytokines - metabolism; Disease Models, Animal; etiological agents; Female; Francisella tularensis; Francisella tularensis - immunology; Francisella tularensis - pathogenicity; Germ-free; Germ-Free Life - immunology; Gnotobiont; Host-Pathogen Interactions - immunology; human population; humans; immunity; Immunity, Innate; Innate immunity; Mice; Mice, Inbred BALB C; Microbiota; Peritoneum - microbiology; Peritoneum - pathology; risk; specific pathogen-free animals; Specific Pathogen-Free Organisms - immunology; Spleen - microbiology; Spleen - pathology; tularemia; Tularemia - immunology; Tularemia - microbiology; Tularemia - pathology; vaccines; virulence; Gnotobiont; Innate immunity; Germ-free; Francisella tularensis; Cellular response

Bacteria that are highly virulent, expressing high infectivity, and able to survive nebulization, pose great risk to the human population. One of these is Francisella tularensis, the etiological agent of tularemia. F. tularensis is a subject of intense scientific interest due to the fact that vaccin...