Differential gene expression profiling of Actinobacillus pleuropneumoniae during induction of primary alveolar macrophage apoptosis in piglets

• Published in: Microbial pathogenesis Vol. 78; pp. 74 - 86
• Main Authors: Wang, Lei, Qin, Wanhai, Ruidong, Zhai, Liu, Shiting, Zhang, Hu, Sun, Changjiang, Feng, Xin, Gu, Jingmin, Du, Chongtao, Han, Wenyu, Langford, P.R., Lei, Liancheng
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2015
• Subjects: Actinobacillus Infections - microbiology; Actinobacillus Infections - physiopathology; Actinobacillus Infections - veterinary; Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae - genetics; Actinobacillus pleuropneumoniae - metabolism; Animals; Apoptosis; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Macrophages, Alveolar - cytology; Macrophages, Alveolar - microbiology; Primary alveolar macrophages; Swine; Swine Diseases - microbiology; Swine Diseases - physiopathology; Actinobacillus pleuropneumoniae; Gene expression; Primary alveolar macrophages; Apoptosis

Actinobacillus pleuropneumoniae (A. pleuropneumoniae) is the causative agent of porcine pleuropneumonia, a disease that causes serious problems for the swine industry. Successful infection by this bacterium requires breaking the first line of defence in the lungs, the primary alveolar macrophages (P...