Enzymatically releasable polyethylene glycol – host defense peptide conjugates with improved activity and biocompatibility

• Published in: Journal of controlled release Vol. 339; pp. 220 - 231
• Main Authors: Drayton, Matthew, Alford, Morgan A., Pletzer, Daniel, Haney, Evan F., Machado, Yoan, Luo, Haiming D., Overall, Christopher M., Kizhakkedathu, Jayachandran N., Hancock, Robert E.W., Straus, Suzana K.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.11.2021
• Subjects: abscess; Animals; Antimicrobial Cationic Peptides; antimicrobial properties; biocompatibility; Bioconjugates; biological half-life; Drug Resistance, Multiple, Bacterial; Host defense peptides (HDPs); induced resistance; Matrix metalloproteinases (MMPs); metalloproteinases; Methicillin-Resistant Staphylococcus aureus; Mice; microbial load; Microbial Sensitivity Tests; minimum inhibitory concentration; multiple drug resistance; peptides; polyethylene glycol; Polyethylene glycol (PEG); Polyethylene Glycols; toxicity; Matrix metalloproteinases (MMPs); Bioconjugates; Polyethylene glycol (PEG); Host defense peptides (HDPs)

Host defense peptides (HDPs) have been the subject of great interest for the treatment of multidrug-resistant bacterial infections due to their multimodal activity and low induction of resistance. However, aggregation, toxicity, and short biological half-life have limited their applicability for cli...