Immunophenotyping Tracks Motor Progression in Parkinson’s Disease Associated with a TH Mutation

• Published in: Journal of Parkinson's disease Vol. 14; no. 4; pp. 883 - 888
• Main Authors: Gopinath, Adithya, Ramirez-Zamora, Adolfo, Franks, Stephen, Riaz, Tabish, Smith, Aidan, Dizon, Glen, Hornstein, Lauryn, Follett, Jordan, Swartz, Camille, Bravo, Jonathan, Kugelmann, E. Lee, Farrer, Matthew, Okun, Michael S., Khoshbouei, Habibeh
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 04.06.2024; Sage Publications Ltd; IOS Press
• Subjects: Biomarkers; Case Report; Disease Progression; Dopamine Plasma Membrane Transport Proteins - genetics; Dopamine transporter; Female; Follow-Up Studies; Genetic factors; Humans; Immunophenotyping; Leukocytes (mononuclear); Leukocytes, Mononuclear - metabolism; Levodopa; Longitudinal Studies; Middle Aged; Movement disorders; Mutation; Neurodegenerative diseases; Parkinson Disease - blood; Parkinson Disease - diagnosis; Parkinson Disease - drug therapy; Parkinson Disease - genetics; Parkinson's disease; Patients; Peripheral blood mononuclear cells; Tyrosine 3-monooxygenase; Tyrosine 3-Monooxygenase - genetics; Dopamine transporter; Parkinson’s disease; immunophenotype; tyrosine hydroxylase

Background: Parkinson’s disease (PD) is the second most common neurodegenerative disorder, with genetic factors accounting for about 15% of cases. There is a significant challenge in tracking disease progression and treatment response, crucial for developing new therapies. Traditional methods like i...