Anti-HIV Activities of Intramolecular G4 and Non-G4 Oligonucleotides

• Published in: Nucleic acid therapeutics Vol. 27; no. 1; pp. 56 - 66
• Main Authors: Prokofjeva, Maria, Tsvetkov, Vladimir, Basmanov, Dmitry, Varizhuk, Anna, Lagarkova, Maria, Smirnov, Igor, Prusakov, Kirill, Klinov, Dmitry, Prassolov, Vladimir, Pozmogova, Galina, Mikhailov, Sergey N.
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.02.2017
• Subjects: Aptamers, Nucleotide - chemical synthesis; Aptamers, Nucleotide - chemistry; Aptamers, Nucleotide - genetics; Aptamers, Nucleotide - pharmacology; Binding Sites; Brief Communication; Cell Proliferation - drug effects; Cell Survival - drug effects; Deoxyribonucleic acid; DNA; DNA - chemistry; Dose-Response Relationship, Drug; G-Quadruplexes; HIV; HIV Infections - therapy; HIV-1 - drug effects; Human immunodeficiency virus; Humans; Jurkat Cells; Lentivirus; Molecular biology; Molecular Docking Simulation; Molecular Dynamics Simulation; Nucleic Acid Conformation; Phosphorothioate Oligonucleotides - chemical synthesis; Phosphorothioate Oligonucleotides - chemistry; Phosphorothioate Oligonucleotides - pharmacology; Phosphorus Compounds - chemistry; Promoter Regions, Genetic - genetics; Proto-Oncogene Proteins c-bcl-2 - genetics; Retroviridae; Structure-Activity Relationship; Topology; inhibition; HIV; aptamer; phosphorothioate; lentivirus
• ISSN: 2159-3337; 2159-3345; 2159-3345
• DOI: 10.1089/nat.2016.0624

New natural and chemically modified DNA aptamers that inhibit HIV-1 activity at submicromolar concentrations (presumably via preventing viral entry into target cells) are reported. The new DNA aptamers were developed based on known intramolecular G-quadruplexes (G4s) that were functionally unrelated...