Enzymology of acyl chain macrocyclization in natural product biosynthesis

• Published in: Chemical communications (Cambridge, England) no. 3; pp. 297 - 307
• Main Authors: Kohli, Rahul M., Walsh, Christopher T.
• Format: Journal Article
• Language: English
• Published: England 07.02.2003
• Subjects: amino acids; Animals; antibiotics; bioactive properties; Biological Factors - biosynthesis; Biopolymers - biosynthesis; biosynthesis; catalysts; catalytic activity; chemical bonding; Cyclization; enzymes; Enzymes - chemistry; Enzymes - metabolism; Enzymes - physiology; enzymology; Humans; macrocyclization reactions; Multienzyme Complexes - chemistry; Multienzyme Complexes - metabolism; Multienzyme Complexes - physiology; nonribosomal peptides; pathogenesis; Peptide Library; polyketides
• ISSN: 1359-7345; 1364-548X; 1364-548X
• DOI: 10.1039/b208333g

Polyketides and nonribosomal peptides constitute a large and diverse set of natural products with biological activity in microbial survival and pathogenesis, as well as broad pharmacological utility as antineoplastics, antibiotics or immunosupressants. These molecules are biosynthesized by the order...