Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation
Exosomes, the smallest subgroup of extracellular vesicles, have been recognized as extracellular organelles that contain genetic and proteomic information for long distance intercellular communication. Exosome-based drug delivery is currently a subject of intensive research. Here, we report a novel...
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| Published in | Journal of controlled release Vol. 243; pp. 160 - 171 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
10.12.2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0168-3659 1873-4995 |
| DOI | 10.1016/j.jconrel.2016.10.008 |
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| Abstract | Exosomes, the smallest subgroup of extracellular vesicles, have been recognized as extracellular organelles that contain genetic and proteomic information for long distance intercellular communication. Exosome-based drug delivery is currently a subject of intensive research. Here, we report a novel strategy to produce nanoscale exosome-mimics (EMs) in sufficient quantity for gene delivery in cancer both in vitro and in vivo. Size-controllable EMs were generated at a high yield by serial extrusion of non-tumorigenic epithelial MCF-10A cells through filters with different pore sizes. siRNA was then encapsulated into the EMs by electroporation. Biosafety and uptake efficiency of the EMs were evaluated both in vitro and in vivo. The mechanism underlying their cellular endocytosis was also studied.
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| AbstractList | Exosomes, the smallest subgroup of extracellular vesicles, have been recognized as extracellular organelles that contain genetic and proteomic information for long distance intercellular communication. Exosome-based drug delivery is currently a subject of intensive research. Here, we report a novel strategy to produce nanoscale exosome-mimics (EMs) in sufficient quantity for gene delivery in cancer both in vitro and in vivo. Size-controllable EMs were generated at a high yield by serial extrusion of non-tumorigenic epithelial MCF-10A cells through filters with different pore sizes. siRNA was then encapsulated into the EMs by electroporation. Biosafety and uptake efficiency of the EMs were evaluated both in vitro and in vivo. The mechanism underlying their cellular endocytosis was also studied. Exosomes, the smallest subgroup of extracellular vesicles, have been recognized as extracellular organelles that contain genetic and proteomic information for long distance intercellular communication. Exosome-based drug delivery is currently a subject of intensive research. Here, we report a novel strategy to produce nanoscale exosome-mimics (EMs) in sufficient quantity for gene delivery in cancer both in vitro and in vivo. Size-controllable EMs were generated at a high yield by serial extrusion of non-tumorigenic epithelial MCF-10A cells through filters with different pore sizes. siRNA was then encapsulated into the EMs by electroporation. Biosafety and uptake efficiency of the EMs were evaluated both in vitro and in vivo. The mechanism underlying their cellular endocytosis was also studied. [Display omitted] |
| Author | Zhang, Aili Lee, Robert J. Wang, Xiaobing Zhu, Jing Yang, Zhaogang Chiang, Chiling Lee, L. James Xie, Jing Wang, Xinmei Teng, Lesheng Chen, Feng Yu, Bo Kuang, Tairong Chen, Zhou Kang, Chen |
| Author_xml | – sequence: 1 givenname: Zhaogang orcidid: 0000-0002-6350-4455 surname: Yang fullname: Yang, Zhaogang organization: Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA – sequence: 2 givenname: Jing surname: Xie fullname: Xie, Jing organization: School of Life Sciences, Jilin University, Changchun, 130012, China – sequence: 3 givenname: Jing surname: Zhu fullname: Zhu, Jing organization: College of Pharmacy, The Ohio State University, Columbus, OH 43212, USA – sequence: 4 givenname: Chen surname: Kang fullname: Kang, Chen organization: College of Pharmacy, The Ohio State University, Columbus, OH 43212, USA – sequence: 5 givenname: Chiling surname: Chiang fullname: Chiang, Chiling organization: Division of Hematology, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43212, USA – sequence: 6 givenname: Xinmei surname: Wang fullname: Wang, Xinmei organization: Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA – sequence: 7 givenname: Xiaobing surname: Wang fullname: Wang, Xiaobing organization: Tumor Biomarker Research Center, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China – sequence: 8 givenname: Tairong surname: Kuang fullname: Kuang, Tairong organization: Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA – sequence: 9 givenname: Feng surname: Chen fullname: Chen, Feng organization: Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA – sequence: 10 givenname: Zhou surname: Chen fullname: Chen, Zhou organization: Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA – sequence: 11 givenname: Aili surname: Zhang fullname: Zhang, Aili organization: Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA – sequence: 12 givenname: Bo surname: Yu fullname: Yu, Bo organization: Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA – sequence: 13 givenname: Robert J. surname: Lee fullname: Lee, Robert J. organization: College of Pharmacy, The Ohio State University, Columbus, OH 43212, USA – sequence: 14 givenname: Lesheng surname: Teng fullname: Teng, Lesheng email: tenglesheng@jlu.edu.cn organization: School of Life Sciences, Jilin University, Changchun, 130012, China – sequence: 15 givenname: L. James surname: Lee fullname: Lee, L. James email: lee.31@osu.edu organization: Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27742443$$D View this record in MEDLINE/PubMed |
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| Keywords | Electroporation Endocytosis siRNA Exosome MCF-7 |
| Language | English |
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| Title | Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation |
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