Both isoforms of human UDP-glucose:glycoprotein glucosyltransferase are enzymatically active

• Published in: Glycobiology (Oxford) Vol. 24; no. 4; pp. 344 - 350
• Main Authors: Takeda, Yoichi, Seko, Akira, Hachisu, Masakazu, Daikoku, Shusaku, Izumi, Masayuki, Koizumi, Akihiko, Fujikawa, Kohki, Kajihara, Yasuhiro, Ito, Yukishige
• Format: Journal Article
• Language: English
• Published: England 01.04.2014
• Subjects: Enzyme Activation; Glucosyltransferases - metabolism; Humans; Isoenzymes - metabolism; Molecular Structure; UDP-glucose:glycoprotein glucosyltransferase; high-mannose-type glycan; calnexin; calreticulin cycle; endoplasmic reticulum glycoprotein quality control

Being recognized as an important constituent of the glycoprotein folding cycle, uridine diphosphate-glucose:glycoprotein glucosyltransferase (UGGT) has been a subject of intense study. Up to now, it is two isoforms, UGGT1 and 2 have been identified, which share ∼ 50% amino acid identity. UGGT1 is a...