Sodium, ATP, and intracellular pH transients during reversible complete ischemia of dog cerebrum

• Published in: Stroke (1970) Vol. 22; no. 2; pp. 233 - 241
• Main Authors: ELEFF, S. M, MARUKI, Y, MONSEIN, L. H, TRAYSTMAN, R. J, BRYAN, R. N, KOEHLER, R. C
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.02.1991
• Subjects: Adenosine Triphosphate - metabolism; Animals; Biological and medical sciences; Brain - pathology; Brain Ischemia - diagnostic imaging; Brain Ischemia - metabolism; Brain Ischemia - physiopathology; Cerebral Angiography; Cerebrovascular Circulation; Dogs; Hydrogen-Ion Concentration; Intracellular Membranes - metabolism; Magnetic Resonance Spectroscopy; Medical sciences; Microspheres; Neck; Nervous system involvement in other diseases. Miscellaneous; Neurology; Sodium - metabolism; Tourniquets; Fissipedia; Brain; Carnivora; Energy metabolism; Nervous system diseases; Exploration; NMR spectrometry; Transitory; Vertebrata; Experimental disease; Mammalia; Ischemia; Sodium; Animal; PH; Intracellular; ATP; Dog; Cerebrovascular disease

We tested the hypotheses that with the onset of cerebral ischemia, massive cellular sodium influx does not occur until adenosine triphosphate is fully depleted and that on reperfusion, neuronal sodium efflux does not occur until adenosine triphosphate is fully restored. We examined the temporal rela...