Opportunistic infections in acquired immune deficiency syndrome result from synergistic defects of both the natural and adaptive components of cellular immunity

• Published in: The Journal of clinical investigation Vol. 78; no. 1; pp. 115 - 123
• Main Authors: Siegal, F P, Lopez, C, Fitzgerald, P A, Shah, K, Baron, P, Leiderman, I Z, Imperato, D, Landesman, S
• Format: Journal Article
• Language: English
• Published: Ann Arbor, MI American Society for Clinical Investigation 01.07.1986
• Subjects: Acquired Immunodeficiency Syndrome - complications; Acquired Immunodeficiency Syndrome - immunology; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface - analysis; Biological and medical sciences; Female; Hemophilia A - complications; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infection - etiology; Interferon Type I - biosynthesis; Killer Cells, Natural - immunology; Killer Cells, Natural - physiology; Leukocyte Count; Male; Medical sciences; Sexual Behavior; Skin Tests; T-Lymphocytes - immunology; T-Lymphocytes - physiology; Human; Infection; Immunopathology; Pathogenesis; Viral disease; T-Lymphocyte; AIDS; Hemopathy; Cellular immunity; Lymphokine; Opportunist; Large granular lymphocyte

We evaluated the cellular immunity of 408 clinically stratified subjects at risk for acquired immune deficiency syndrome (AIDS), to define the role of interferon-alpha production deficits in the pathogenesis of opportunistic infections (OI). We followed 115 prospectively for up to 45 mo. Onset of OI...