Plasma-Diluted Thrombin Time to Measure Dabigatran Concentrations During Dabigatran Etexilate Therapy

New anticoagulants, like the orally available direct thrombin inhibitor (DTI) dabigatran etexilate, have recently been introduced into the market for venous thromboembolic prophylaxis and for stroke prevention in atrial fibrillation. While dabigatran has been approved for use without the need for ro...

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Bibliographic Details
Published inAmerican journal of clinical pathology Vol. 137; no. 4; pp. 572 - 574
Main Authors AVECILLA, Scott T, FERRELL, Chris, CHANDLER, Wayne L, REYES, Morayma
Format Journal Article
LanguageEnglish
Published Chicago, IL American Society of Clinical Pathologists 01.04.2012
Oxford University Press
Subjects
Antithrombin Proteins - administration & dosage
Antithrombin Proteins - therapeutic use
Atrial Fibrillation - drug therapy
Benzimidazoles - administration & dosage
Benzimidazoles - therapeutic use
Biological and medical sciences
Dabigatran
Dose-Response Relationship, Drug
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Pyridines - administration & dosage
Pyridines - therapeutic use
Stroke - prevention & control
Thrombin Time
Serine endopeptidases
Enzyme
Thrombin inhibitor
Thrombin
Dabigatran etexilate
Concentration
Dabigatran
Thrombin time
Blood plasma
Peptidases
Anatomic pathology
Treatment
Hydrolases
Inhibitor
Quantitative analysis
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Summary:New anticoagulants, like the orally available direct thrombin inhibitor (DTI) dabigatran etexilate, have recently been introduced into the market for venous thromboembolic prophylaxis and for stroke prevention in atrial fibrillation. While dabigatran has been approved for use without the need for routine therapeutic monitoring, there are clinical scenarios in which monitoring can help guide clinical management. We report herein the application of a recently described plasma-diluted thrombin time (DTI assay) used to monitor intravenous DTI as a useful and easily implemented method to monitor oral DTIs.
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ISSN:0002-9173
1943-7722
DOI:10.1309/AJCPAU7OQM0SRPZQ