Viscoelastometric-guided early fibrinogen concentrate replacement during postpartum haemorrhage: OBS2, a double-blind randomized controlled trial

• Published in: British journal of anaesthesia : BJA Vol. 119; no. 3; pp. 411 - 421
• Main Authors: Collins, P.W., Cannings-John, R., Bruynseels, D., Mallaiah, S., Dick, J., Elton, C., Weeks, A.D., Sanders, J., Aawar, N., Townson, J., Hood, K., Hall, J.E., Collis, R.E.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2017; Oxford University Press
• Subjects: Adult; Double-Blind Method; Female; fibrinogen; Fibrinogen - therapeutic use; Humans; Middle Aged; postpartum haemorrhage; Postpartum Hemorrhage - drug therapy; Thrombelastography - methods; Treatment Outcome; viscoelastometry; Young Adult; fibrinogen; postpartum haemorrhage; viscoelastometry

Postpartum haemorrhage (PPH) can be exacerbated by haemostatic failure. We hypothesized that early fibrinogen replacement, guided by viscoelastometric testing, reduces blood product usage and bleed size. Women with PPH 1000–1500 ml were enrolled. If Fibtem A5 was ≤15 mm and bleeding continued, subje...