Metabolomics and mass spectrometry imaging reveal the chronic toxicity of indoxacarb to adult zebrafish (Danio rerio) livers

• Published in: Journal of hazardous materials Vol. 453; p. 131304
• Main Authors: Ma, Lianlian, Yin, Zhibin, Xie, Qingrong, Xu, Yizhu, Chen, Yingying, Huang, Yudi, Li, Zhen, Zhu, Xinhai, Zhao, Yuhui, Wen, Wenlin, Xu, Hanhong, Wu, Xinzhou
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.07.2023
• Subjects: adults; alanine transaminase; amino acids; Animals; catalase; chronic exposure; chronic toxicity; Danio rerio; environmental assessment; Indoxacarb; Insecticides - metabolism; Insecticides - toxicity; liver; Liver - metabolism; Mass Spectrometry; Mass spectrometry imaging; metabolic detoxification; metabolites; Metabolomics; Metabolomics - methods; spatial variation; Toxicity mechanism; Water Pollutants, Chemical - metabolism; Water Pollutants, Chemical - toxicity; Zebrafish; Zebrafish - metabolism; Metabolomics; Toxicity mechanism; Zebrafish; Indoxacarb; Mass spectrometry imaging

Indoxacarb is a widely used insecticide in the prevention and control of agricultural pests, whereas its negative effects on non-target organisms remain largely unclear. Herein, we demonstrated the integrated metabolomics and mass spectrometry imaging (MSI) methods to investigate the chronic exposur...