Loss of Perivascular Adipose Tissue on Peroxisome Proliferator–Activated Receptor-γ Deletion in Smooth Muscle Cells Impairs Intravascular Thermoregulation and Enhances Atherosclerosis

• Published in: Circulation (New York, N.Y.) Vol. 126; no. 9; pp. 1067 - 1078
• Main Authors: Chang, Lin, Villacorta, Luis, Li, Rongxia, Hamblin, Milton, Xu, Wei, Dou, Chunyan, Zhang, Jifeng, Wu, Jiarui, Zeng, Rong, Chen, Y. Eugene
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 28.08.2012
• Subjects: Adaptation, Physiological - physiology; Adipocytes - metabolism; Adipose Tissue - pathology; Adipose Tissue - physiopathology; Adipose Tissue, Brown - metabolism; Animals; Aorta; Apolipoproteins E - deficiency; Apolipoproteins E - genetics; Atherosclerosis - etiology; Atherosclerosis - prevention & control; Biological and medical sciences; Blood and lymphatic vessels; Blood vessels and receptors; Body Temperature Regulation - physiology; Cardiology. Vascular system; Carotid Arteries; Cold Temperature; Cytokines - metabolism; Diet, Atherogenic; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Endothelium, Vascular - pathology; Endothelium, Vascular - physiopathology; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - physiology; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular - pathology; Muscle, Smooth, Vascular - physiopathology; PPAR gamma - deficiency; PPAR gamma - genetics; Prostaglandins I - physiology; Proteomics; Vertebrates: cardiovascular system; adipose tissue, brown; Temperature; Adipose tissue; Cold; Thermoregulation; perivascular; Environmental factor; Smooth muscle; Cardiovascular disease; PPAR γ; Peroxisome proliferator; Vascular disease; cold temperature; Atherosclerosis; Deletion

Perivascular adipose tissue (PVAT) surrounds most vessels and shares common features with brown adipose tissue (BAT). Although adaptive thermogenesis in BAT increases energy expenditure and is beneficial for metabolic diseases, little is known about the role of PVAT in vascular diseases such as athe...