Effect of pistachio consumption on the modulation of urinary gut microbiota-related metabolites in prediabetic subjects

• Published in: The Journal of nutritional biochemistry Vol. 45; pp. 48 - 53
• Main Authors: Hernández-Alonso, Pablo, Cañueto, Daniel, Giardina, Simona, Salas-Salvadó, Jordi, Cañellas, Nicolau, Correig, Xavier, Bulló, Mònica
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2017
• Subjects: carbohydrates; clinical trials; creatinine; Cresols - urine; Diet; digestive system; dimethylamine; Dimethylamines - urine; discriminant analysis; Female; Gastrointestinal Microbiome - physiology; Hippurates - urine; Humans; Insulin resistance; intestinal microorganisms; Magnetic Resonance Spectroscopy; Male; metabolism; metabolites; metabolome; Metabolomics; Methylamines - urine; Microbiota; Middle Aged; multivariate analysis; noninsulin-dependent diabetes mellitus; nuclear magnetic resonance spectroscopy; nutrient content; Nuts; p-cresol; Pistachios; Pistacia; Prediabetes; Prediabetic State - diet therapy; Prediabetic State - urine; Principal Component Analysis; sulfates; tricarboxylic acid cycle; trimethylamine; urine; Urine - chemistry; TMAO; Metabolomics; NAFLD; Nuts; E; Microbiota; JRES; MHP; DMA; 1D NOESY-presat; HPLC; D2O; CD; ML-PLS-DA; HMDB; BMRB; EPIRDEM; CI; T2D; TMA; Pistachios; PQN; Prediabetes; PCA; CVD; TSP; NMR; QqQ/MS; TCA; PD; Insulin resistance; TCI

The specific nutritional composition of nuts could affect different metabolic pathways involved in a broad range of metabolic diseases. We therefore investigated whether chronic consumption of pistachio nuts modifies the urine metabolome in prediabetic subjects. We designed a randomized crossover cl...