Glycidol induces axonopathy by adult-stage exposure and aberration of hippocampal neurogenesis affecting late-stage differentiation by developmental exposure in rats

• Published in: Toxicological sciences Vol. 134; no. 1; pp. 140 - 154
• Main Authors: Akane, Hirotoshi, Shiraki, Ayako, Imatanaka, Nobuya, Akahori, Yumi, Itahashi, Megu, Ohishi, Takumi, Mitsumori, Kunitoshi, Shibutani, Makoto
• Format: Journal Article
• Language: English
• Published: United States 01.07.2013
• Subjects: Aging - pathology; Animals; Apoptosis - drug effects; Axons - drug effects; Axons - pathology; Cell Differentiation - drug effects; Dose-Response Relationship, Drug; Epoxy Compounds - toxicity; Female; Hippocampus - drug effects; Hippocampus - embryology; Hippocampus - growth & development; Hippocampus - pathology; Male; Neurogenesis - drug effects; Neurons - drug effects; Neurons - pathology; Pregnancy; Prenatal Exposure Delayed Effects - chemically induced; Prenatal Exposure Delayed Effects - pathology; Propanols - toxicity; Rats; Rats, Sprague-Dawley; neurogenesis; axonopathy; neurotoxicity; hippocampal dentate gyrus; γ-aminobutyric acid-ergic interneurons; glycidol

To investigate the neurotoxicity profile of glycidol and its effect on developmental hippocampal neurogenesis, pregnant Sprague Dawley rats were given drinking water containing 0, 100, 300, or 1000 ppm glycidol from gestational day 6 until weaning on day 21 after delivery. At 1000 ppm, dams showed p...