Altered renal expression of aquaporin-2 water channels in rats with experimental two-kidney, one clip hypertension

• Published in: Journal of Korean medical science Vol. 16; no. 4; pp. 462 - 466
• Main Authors: Lee, J, Oh, Y, Kim, S W
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Academy of Medical Sciences 01.08.2001
• Subjects: Adenylyl Cyclases - metabolism; Animals; Aquaporin 2; Aquaporin 6; Aquaporins - analysis; Blood Pressure; Cyclic AMP - biosynthesis; Hypertension, Renovascular - metabolism; Kidney - chemistry; Male; Rats; Rats, Sprague-Dawley

The present study was aimed at examining the regulation of aquaporin (AQP)-2 water channels in the kidney in two-kidney, one clip (2K1C) hypertension. Rats were made 2K1C hypertensive for 6 weeks, and their expression of AQP2 channel proteins was determined in the clipped and contralateral kidneys....