Quantitative analysis of 11-nor-9-carboxy-tetrahydrocannbinol (THC–COOH) in urine by LC–MS/MS following a simple filtration
•Develop a rapid LC–MS/MS method for THC–COOH in urine for pain management.•Fully validate the analytical method according to recommended guidelines.•The first to describe an analytical clean-up procedure using a simple filtration column.•Compare two types of filtration columns commercially availabl...
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Published in | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 957; pp. 77 - 83 |
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Format | Journal Article |
Language | English |
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Elsevier B.V
15.04.2014
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Abstract | •Develop a rapid LC–MS/MS method for THC–COOH in urine for pain management.•Fully validate the analytical method according to recommended guidelines.•The first to describe an analytical clean-up procedure using a simple filtration column.•Compare two types of filtration columns commercially available.
Quantification methods utilizing liquid chromatography tandem mass spectrometry (LC–MS/MS) are common in clinical and forensic toxicology laboratories and the efficiency and rapidity of such methods continues to evolve. In most cases, urine drug confirmation does not require a drug extraction and can quickly and easily be accomplished with a dilution followed by sample filtration. The report describes the validation of a simple confirmation method for 11-nor-9-carboxy-tetrahydrocannabinol (THC–COOH) and compared two types of filter extraction columns for sample clean-up. The method achieved a linear range of 10–3000ng/mL, acceptable bias (−4.7–2.6%) and precision (0.9–6.9%) and autosampler stability up to 72h. Universal filter columns offered less variable recovery over the linear range and fewer matrix interferences compared to THC–COOH specific filter columns. Authentic specimens testing positive for THC–COOH by LC–MS/MS were in good agreement with typically used GC–MS methods. |
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AbstractList | •Develop a rapid LC–MS/MS method for THC–COOH in urine for pain management.•Fully validate the analytical method according to recommended guidelines.•The first to describe an analytical clean-up procedure using a simple filtration column.•Compare two types of filtration columns commercially available.
Quantification methods utilizing liquid chromatography tandem mass spectrometry (LC–MS/MS) are common in clinical and forensic toxicology laboratories and the efficiency and rapidity of such methods continues to evolve. In most cases, urine drug confirmation does not require a drug extraction and can quickly and easily be accomplished with a dilution followed by sample filtration. The report describes the validation of a simple confirmation method for 11-nor-9-carboxy-tetrahydrocannabinol (THC–COOH) and compared two types of filter extraction columns for sample clean-up. The method achieved a linear range of 10–3000ng/mL, acceptable bias (−4.7–2.6%) and precision (0.9–6.9%) and autosampler stability up to 72h. Universal filter columns offered less variable recovery over the linear range and fewer matrix interferences compared to THC–COOH specific filter columns. Authentic specimens testing positive for THC–COOH by LC–MS/MS were in good agreement with typically used GC–MS methods. Quantification methods utilizing liquid chromatography tandem mass spectrometry (LC-MS/MS) are common in clinical and forensic toxicology laboratories and the efficiency and rapidity of such methods continues to evolve. In most cases, urine drug confirmation does not require a drug extraction and can quickly and easily be accomplished with a dilution followed by sample filtration. The report describes the validation of a simple confirmation method for 11-nor-9-carboxy-tetrahydrocannabinol (THC-COOH) and compared two types of filter extraction columns for sample clean-up. The method achieved a linear range of 10-3000ng/mL, acceptable bias (-4.7-2.6%) and precision (0.9-6.9%) and autosampler stability up to 72h. Universal filter columns offered less variable recovery over the linear range and fewer matrix interferences compared to THC-COOH specific filter columns. Authentic specimens testing positive for THC-COOH by LC-MS/MS were in good agreement with typically used GC-MS methods. Quantification methods utilizing liquid chromatography tandem mass spectrometry (LC-MS/MS) are common in clinical and forensic toxicology laboratories and the efficiency and rapidity of such methods continues to evolve. In most cases, urine drug confirmation does not require a drug extraction and can quickly and easily be accomplished with a dilution followed by sample filtration. The report describes the validation of a simple confirmation method for 11-nor-9-carboxy-tetrahydrocannabinol (THC-COOH) and compared two types of filter extraction columns for sample clean-up. The method achieved a linear range of 10-3000 ng/mL, acceptable bias (-4.7-2.6%) and precision (0.9-6.9%) and autosampler stability up to 72 h. Universal filter columns offered less variable recovery over the linear range and fewer matrix interferences compared to THC-COOH specific filter columns. Authentic specimens testing positive for THC-COOH by LC-MS/MS were in good agreement with typically used GC-MS methods. |
Author | Rumpler, Marc J. |
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Cites_doi | 10.1016/j.jchromb.2009.04.047 10.1016/j.jpba.2007.02.006 10.1093/jat/32.4.292 10.1093/jat/21.6.433 10.1016/S1044-0305(03)00574-9 10.1016/j.chroma.2010.01.010 10.1016/S1001-0742(09)60099-1 10.1021/am100616b 10.1016/j.jchromb.2005.11.009 10.1016/S0021-9673(00)01188-2 10.1023/B:PHAM.0000003390.51761.3d 10.1016/j.jchromb.2006.12.030 10.1039/c2an16248b 10.1002/jssc.200600535 10.1002/jms.2034 10.1016/j.chroma.2011.08.075 10.1093/jat/33.8.456 10.1021/ac020361s |
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Keywords | LC–MS/MS THC–COOH Filtration |
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Snippet | •Develop a rapid LC–MS/MS method for THC–COOH in urine for pain management.•Fully validate the analytical method according to recommended guidelines.•The first... Quantification methods utilizing liquid chromatography tandem mass spectrometry (LC-MS/MS) are common in clinical and forensic toxicology laboratories and the... |
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SubjectTerms | Acceptability Analysis of Variance Chromatography, Liquid - methods Cleaning Dronabinol - analogs & derivatives Dronabinol - urine Drugs Extraction Filtration Filtration - methods Forensic toxicology Humans LC–MS/MS Limit of Detection Linear Models Quantitative analysis Reproducibility of Results Tandem Mass Spectrometry - methods THC–COOH Urine |
Title | Quantitative analysis of 11-nor-9-carboxy-tetrahydrocannbinol (THC–COOH) in urine by LC–MS/MS following a simple filtration |
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