Release of taurine and glutamate contributes to cell volume regulation in human retinal Müller cells: differences in modulation by calcium

• Published in: Journal of neurophysiology Vol. 120; no. 3; pp. 973 - 984
• Main Authors: Netti, Vanina, Pizzoni, Alejandro, Pérez-Domínguez, Martha, Ford, Paula, Pasantes-Morales, Herminia, Ramos-Mandujano, Gerardo, Capurro, Claudia
• Format: Journal Article
• Language: English
• Published: United States 01.09.2018
• Subjects: cell volume regulation; taurine; volume-regulated anion channel; human Müller cells; glutamate

Neuronal activity in the retina generates osmotic gradients that lead to Müller cell swelling, followed by a regulatory volume decrease (RVD) response, partially due to the isoosmotic efflux of KCl and water. However, our previous studies in a human Müller cell line (MIO-M1) demonstrated that an imp...