Novel Modulator for Endothelial Adhesion Molecules Adipocyte-Derived Plasma Protein Adiponectin

• Published in: Circulation (New York, N.Y.) Vol. 100; no. 25; pp. 2473 - 2476
• Main Authors: Ouchi, Noriyuki, Kihara, Shinji, Arita, Yukio, Maeda, Kazuhisa, Kuriyama, Hiroshi, Okamoto, Yoshihisa, Hotta, Kikuko, Nishida, Makoto, Takahashi, Masahiko, Nakamura, Tadashi, Yamashita, Shizuya, Funahashi, Tohru, Matsuzawa, Yuji
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 21.12.1999; American Heart Association, Inc
• Subjects: Adipocytes - chemistry; Adipocytes - metabolism; Adiponectin; Adult; Aged; Aorta; Biological and medical sciences; Blotting, Northern; Body Mass Index; Cardiology. Vascular system; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Cell Adhesion Molecules - biosynthesis; Cell Adhesion Molecules - genetics; Cells, Cultured; Coronary Disease - blood; Coronary heart disease; DNA, Complementary - genetics; E-Selectin - biosynthesis; E-Selectin - genetics; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation - drug effects; Heart; Humans; Intercellular Adhesion Molecule-1 - biosynthesis; Intercellular Adhesion Molecule-1 - genetics; Intercellular Signaling Peptides and Proteins; Male; Medical sciences; Middle Aged; Monocytes - cytology; Obesity - blood; Obesity - complications; Proteins - isolation & purification; Proteins - pharmacology; Proteins - physiology; Risk Factors; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Vascular Cell Adhesion Molecule-1 - biosynthesis; Vascular Cell Adhesion Molecule-1 - genetics; Human; Adipocyte; Vascular cell adhesion molecule 1; Intercellular adhesion molecule 1; Pathogenesis; Cardiovascular disease; Adhesion; Coronary heart disease; Endothelium

Background —Among the many adipocyte-derived endocrine factors, we recently found an adipocyte-specific secretory protein, adiponectin, which was decreased in obesity. Although obesity is associated with increased cardiovascular mortality and morbidity, the molecular basis for the link between obesi...