The isolation and identification of two compounds with predominant radical scavenging activity in hempseed (seed of Cannabis sativa L.)
► Antioxidant activities of extracts of hempseed residue were examined. ► Two predominant antioxidant compounds were isolated and identified. ► The comparison between compounds and other seed extracts was evaluated. Forty samples were extracted from defatted kernels and hulls of two varieties of hem...
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Published in | Food chemistry Vol. 134; no. 2; pp. 1030 - 1037 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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15.09.2012
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Abstract | ► Antioxidant activities of extracts of hempseed residue were examined. ► Two predominant antioxidant compounds were isolated and identified. ► The comparison between compounds and other seed extracts was evaluated.
Forty samples were extracted from defatted kernels and hulls of two varieties of hempseed (Bama and Yunma No. 1) using 10 different polar solvent systems. The radical scavenging capacity of the extracts was evaluated using 2,2-diphenyl-1-pikrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays and the total phenolic content was determined by Folin–Ciocalteu’s phenol reagent. The correlation analysis indicated that the antioxidants in hempseed belonged to phenolic and DPPH assay was suitable for evaluating the radical scavenging activity. Two compounds, with predominant antiradical activity, were isolated in 60% ethanol extract of hempseed hull using macroporous resin absorption, LH-20 gel chromatography, and high performance liquid chromatography methods, which were identified as N-trans-caffeoyltyramine and cannabisin B by high-resolution mass spectra, nuclear magnetic resonance spectra, and ultraviolet data. The two compounds exhibited significant high DPPH scavenging activity and protective effect against in vitro oxidation of human low-density lipoprotein compared with extracts from flaxseed, grape seed, and soybean. This suggests that hempseed hull extract is a potential source of natural antioxidants, which could be added to dietary supplements to help prevent oxidative stress. |
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AbstractList | ► Antioxidant activities of extracts of hempseed residue were examined. ► Two predominant antioxidant compounds were isolated and identified. ► The comparison between compounds and other seed extracts was evaluated.
Forty samples were extracted from defatted kernels and hulls of two varieties of hempseed (Bama and Yunma No. 1) using 10 different polar solvent systems. The radical scavenging capacity of the extracts was evaluated using 2,2-diphenyl-1-pikrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays and the total phenolic content was determined by Folin–Ciocalteu’s phenol reagent. The correlation analysis indicated that the antioxidants in hempseed belonged to phenolic and DPPH assay was suitable for evaluating the radical scavenging activity. Two compounds, with predominant antiradical activity, were isolated in 60% ethanol extract of hempseed hull using macroporous resin absorption, LH-20 gel chromatography, and high performance liquid chromatography methods, which were identified as N-trans-caffeoyltyramine and cannabisin B by high-resolution mass spectra, nuclear magnetic resonance spectra, and ultraviolet data. The two compounds exhibited significant high DPPH scavenging activity and protective effect against in vitro oxidation of human low-density lipoprotein compared with extracts from flaxseed, grape seed, and soybean. This suggests that hempseed hull extract is a potential source of natural antioxidants, which could be added to dietary supplements to help prevent oxidative stress. Forty samples were extracted from defatted kernels and hulls of two varieties of hempseed (Bama and Yunma No. 1) using 10 different polar solvent systems. The radical scavenging capacity of the extracts was evaluated using 2,2-diphenyl-1-pikrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays and the total phenolic content was determined by Folin-Ciocalteu's phenol reagent. The correlation analysis indicated that the antioxidants in hempseed belonged to phenolic and DPPH() assay was suitable for evaluating the radical scavenging activity. Two compounds, with predominant antiradical activity, were isolated in 60% ethanol extract of hempseed hull using macroporous resin absorption, LH-20 gel chromatography, and high performance liquid chromatography methods, which were identified as N-trans-caffeoyltyramine and cannabisin B by high-resolution mass spectra, nuclear magnetic resonance spectra, and ultraviolet data. The two compounds exhibited significant high DPPH() scavenging activity and protective effect against in vitro oxidation of human low-density lipoprotein compared with extracts from flaxseed, grape seed, and soybean. This suggests that hempseed hull extract is a potential source of natural antioxidants, which could be added to dietary supplements to help prevent oxidative stress. |
Author | Li, Xiaohui Zhang, Hua Chen, Tianpeng He, Jinfeng Hao, Jianxiong Zhang, Jianchun Li, Lite |
Author_xml | – sequence: 1 givenname: Tianpeng surname: Chen fullname: Chen, Tianpeng organization: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China – sequence: 2 givenname: Jinfeng surname: He fullname: He, Jinfeng organization: The Research Center of China-Hemp Materials of The Quartermaster Research Institute of The General Logistic Department, Beijing 100082, China – sequence: 3 givenname: Jianchun surname: Zhang fullname: Zhang, Jianchun organization: The Research Center of China-Hemp Materials of The Quartermaster Research Institute of The General Logistic Department, Beijing 100082, China – sequence: 4 givenname: Xiaohui surname: Li fullname: Li, Xiaohui organization: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China – sequence: 5 givenname: Hua surname: Zhang fullname: Zhang, Hua organization: The Research Center of China-Hemp Materials of The Quartermaster Research Institute of The General Logistic Department, Beijing 100082, China – sequence: 6 givenname: Jianxiong surname: Hao fullname: Hao, Jianxiong organization: Hebei University of Science and Technology, Shijiazhuang, Hebei 050054, China – sequence: 7 givenname: Lite surname: Li fullname: Li, Lite email: llt@cau.edu.cn organization: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China |
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Keywords | Cannabis sativa L Cannabisin B DPPH Human low-density lipoprotein (LDL) Total phenolic Free radical scavenging Hempseed Antioxidant N-trans-Caffeoyltyramine Human Seeds Identification Free radical Lipoprotein LDL Phenols Isolation |
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Snippet | ► Antioxidant activities of extracts of hempseed residue were examined. ► Two predominant antioxidant compounds were isolated and identified. ► The comparison... Forty samples were extracted from defatted kernels and hulls of two varieties of hempseed (Bama and Yunma No. 1) using 10 different polar solvent systems. The... |
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SubjectTerms | Antioxidant Biological and medical sciences Cannabis - chemistry Cannabis sativa L Cannabisin B DPPH Food industries Free Radical Scavengers - chemistry Free Radical Scavengers - isolation & purification Free radical scavenging Fundamental and applied biological sciences. Psychology Hempseed Human low-density lipoprotein (LDL) Humans Lipoproteins, LDL - chemistry N-trans-Caffeoyltyramine Oxidation-Reduction Plant Extracts - chemistry Plant Extracts - isolation & purification Seeds - chemistry Total phenolic |
Title | The isolation and identification of two compounds with predominant radical scavenging activity in hempseed (seed of Cannabis sativa L.) |
URI | https://dx.doi.org/10.1016/j.foodchem.2012.03.009 https://www.ncbi.nlm.nih.gov/pubmed/23107724 https://search.proquest.com/docview/1124755321 |
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