Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 27; no. 1; pp. 576 - 588
• Main Authors: Lawrenson, Isobel D, Krebs, Danielle L, Linossi, Edmond M, Zhang, Jian-Guo, McLennan, Tamara J, Collin, Caitlin, McRae, Helen M, Kolesnik, Tatiana B, Koh, Katrina, Britto, Joanne M, Kueh, Andrew J, Sheikh, Bilal N, El-Saafin, Farrah, Nicola, Nicos A, Tan, Seong-Seng, Babon, Jeffrey J, Nicholson, Sandra E, Alexander, Warren S, Thomas, Tim, Voss, Anne K
• Format: Journal Article
• Language: English
• Published: United States 01.01.2017
• Subjects: Animals; Cell Adhesion Molecules, Neuronal - genetics; Cell Adhesion Molecules, Neuronal - metabolism; Cell Movement - physiology; Cerebral Cortex - embryology; Cerebral Cortex - metabolism; Cerebral Cortex - pathology; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; HEK293 Cells; Humans; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurons - metabolism; Phosphorylation; Serine Endopeptidases - genetics; Serine Endopeptidases - metabolism; Suppressor of Cytokine Signaling Proteins - deficiency; Suppressor of Cytokine Signaling Proteins - genetics

Mutations of the reelin gene cause severe defects in cerebral cortex development and profound intellectual impairment. While many aspects of the reelin signaling pathway have been identified, the molecular and ultimate cellular consequences of reelin signaling remain unknown. Specifically, it is unc...