Genetic susceptibility to teratogens: State of the art

• Published in: Reproductive toxicology (Elmsford, N.Y.) Vol. 34; no. 2; pp. 186 - 191
• Main Authors: Cassina, Matteo, Salviati, Leonardo, Di Gianantonio, Elena, Clementi, Maurizio
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier Inc 01.09.2012; Elsevier
• Subjects: Abnormalities, Drug-Induced - genetics; Animals; Biological and medical sciences; Birth defects; Embryology: invertebrates and vertebrates. Teratology; Female; Fundamental and applied biological sciences. Psychology; Genetic Predisposition to Disease; Genetics; Humans; Medical sciences; Models, Animal; Pregnancy; Teratogenicity; Teratogens - toxicity; Teratology. Teratogens; Toxicology; Pregnancy; Genetics; Birth defects; Teratogenicity; State of the art; Newborn diseases; Congenital; Toxicity; Female; Teratogen; Teratology

► Drug-induced teratogenicity is related to both maternal and fetal genetic variants. ► There is still a clear lack of knowledge regarding the genetic risk factors. ► Few epidemiological studies in humans have been reported. ► Few genetic polymorphisms have been suggested to give susceptibility. ► T...