Evaluation of bioactive compounds-loaded chitosan films as a novel and potential diabetic wound dressing material
Delayed wound healing is a major complication of diabetes and the medical treatment of such wounds still remains a challenge. Among the modern wound dressings, film dressings are considered to be one of the major advances in wound management. In the current study, the feasibility of using a previous...
Saved in:
| Published in | Reactive & functional polymers Vol. 145; p. 104369 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
01.12.2019
Elsevier BV |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Delayed wound healing is a major complication of diabetes and the medical treatment of such wounds still remains a challenge. Among the modern wound dressings, film dressings are considered to be one of the major advances in wound management. In the current study, the feasibility of using a previously developed and optimized bioactive compounds-loaded chitosan film formulation as a functional wound dressing material for diabetic wounds was investigated. The antioxidant capacity, as well as the effect of the chitosan films on cell viability was assessed in vitro. Furthermore, the in vivo performance of the films was further evaluated, by using a streptozotocin-induced diabetic rat model. The chitosan film formulation provided a beneficial moist wound environment, reducing the risk of dehydration and favouring the closure of the wounds. Also, it exhibited good antioxidant activity, as well as a proliferative effect and adequate biocompatibility. The in vivo evaluation of the bioactive compounds-loaded chitosan film formulation confirmed that the biofilm stimulated wound contraction and accelerated the wound healing process. The results strongly support that the above mentioned chitosan film seems to be a promising formulation, as well as a potential and novel biomaterial used for wound healing applications. |
|---|---|
| AbstractList | Delayed wound healing is a major complication of diabetes and the medical treatment of such wounds still remains a challenge. Among the modern wound dressings, film dressings are considered to be one of the major advances in wound management. In the current study, the feasibility of using a previously developed and optimized bioactive compounds-loaded chitosan film formulation as a functional wound dressing material for diabetic wounds was investigated. The antioxidant capacity, as well as the effect of the chitosan films on cell viability was assessed in vitro. Furthermore, the in vivo performance of the films was further evaluated, by using a streptozotocin-induced diabetic rat model. The chitosan film formulation provided a beneficial moist wound environment, reducing the risk of dehydration and favouring the closure of the wounds. Also, it exhibited good antioxidant activity, as well as a proliferative effect and adequate biocompatibility. The in vivo evaluation of the bioactive compounds-loaded chitosan film formulation confirmed that the biofilm stimulated wound contraction and accelerated the wound healing process. The results strongly support that the above mentioned chitosan film seems to be a promising formulation, as well as a potential and novel biomaterial used for wound healing applications. |
| ArticleNumber | 104369 |
| Author | Diaconeasa, Zorita Colobatiu, Liora Gavan, Alexandru Mirel, Simona Mihaiu, Marian Rus, Vasile Tomuta, Ioan Potarniche, Adrian-Valentin Mocan, Andrei |
| Author_xml | – sequence: 1 givenname: Liora surname: Colobatiu fullname: Colobatiu, Liora organization: Department of Medical Devices, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania – sequence: 2 givenname: Alexandru surname: Gavan fullname: Gavan, Alexandru email: gavan.alexandru@umfcluj.ro organization: Department of Medical Devices, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania – sequence: 3 givenname: Adrian-Valentin surname: Potarniche fullname: Potarniche, Adrian-Valentin organization: Department of Infectious Diseases, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania – sequence: 4 givenname: Vasile surname: Rus fullname: Rus, Vasile organization: Department of Cell Biology, Histology and Embryology, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania – sequence: 5 givenname: Zorita surname: Diaconeasa fullname: Diaconeasa, Zorita organization: Department of Chemistry, Biochemistry and Molecular Biology, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania – sequence: 6 givenname: Andrei surname: Mocan fullname: Mocan, Andrei organization: Department of Pharmaceutical Botany, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania – sequence: 7 givenname: Ioan surname: Tomuta fullname: Tomuta, Ioan organization: Department of Pharmaceutical Technology and Biopharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania – sequence: 8 givenname: Simona surname: Mirel fullname: Mirel, Simona organization: Department of Medical Devices, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania – sequence: 9 givenname: Marian surname: Mihaiu fullname: Mihaiu, Marian organization: Department of Food Safety and Animal Origin Products, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania |
| BookMark | eNqNkE1LxDAQhoMouK7-h4B47Jo03X4cPIj4BYIXBW8hnUw0S5vUJF3x35tlPXkSBmZg3vcd5jkhh847JOSCsxVnvL7crAIqSGZ2kCY_fI-rkvEu7ypRdwdkwdtGFLyu3w7zLFperHnVHpOTGDeM8SZvFuTzdquGWSXrHfWG9tbnRLtFCn6c_Ox0LAavNGoKHzb5qBw1dhgjVbmo81scqHKaTj6hS1YNVFvVY7JAv3Z2qgPGaN07HVXCkAWn5MioIeLZb1-S17vbl5uH4un5_vHm-qkA0bWpaARjJasrXPdCmLXBpmOqg740RkFXqSqrSuDITMUMq2tAaBvsKzCgoWyMWJLzfe4U_OeMMcmNn4PLJ2UpBOvqlnc8q672Kgg-xoBGTsGOKnxLzuSOstzIP5TljrLcU87--70f8ytbi0FGsOgAtQ0ISWpv_5n0AywElLk |
| CitedBy_id | crossref_primary_10_3390_polym13173015 crossref_primary_10_1039_D3TB00639E crossref_primary_10_1002_mabi_202200014 crossref_primary_10_1016_j_ijbiomac_2021_04_037 crossref_primary_10_3390_molecules28104192 crossref_primary_10_1515_pac_2023_1117 crossref_primary_10_3390_polym14183806 crossref_primary_10_3390_pharmaceutics13101666 crossref_primary_10_3390_pharmaceutics15010281 crossref_primary_10_1016_j_ijbiomac_2022_10_249 crossref_primary_10_3390_jcm10163558 crossref_primary_10_3390_molecules25112699 crossref_primary_10_1016_j_ijbiomac_2020_11_153 crossref_primary_10_1016_j_matchemphys_2020_123044 crossref_primary_10_3390_md19090479 crossref_primary_10_1016_j_arabjc_2022_103766 crossref_primary_10_1016_j_reactfunctpolym_2021_105059 crossref_primary_10_3390_ijms23052899 crossref_primary_10_1016_j_colsurfb_2020_111222 crossref_primary_10_3390_polym12112518 crossref_primary_10_1002_mabi_202100230 crossref_primary_10_1016_j_jddst_2024_105403 crossref_primary_10_3390_ijms241713042 crossref_primary_10_1016_j_tifs_2021_03_053 crossref_primary_10_3390_polym14040724 crossref_primary_10_1016_j_rinma_2023_100396 crossref_primary_10_1016_j_carbpol_2023_121662 crossref_primary_10_1016_j_carbpol_2022_120058 crossref_primary_10_1007_s44174_023_00114_8 crossref_primary_10_1016_j_apmt_2021_101148 crossref_primary_10_3390_ma15041375 crossref_primary_10_1016_j_ijbiomac_2024_132182 crossref_primary_10_12968_jowc_2021_30_Sup9a_XIII crossref_primary_10_1002_app_54665 crossref_primary_10_1016_j_reactfunctpolym_2021_105028 crossref_primary_10_3390_pharmaceutics15020579 crossref_primary_10_1007_s42995_020_00044_0 crossref_primary_10_2147_DDDT_S419361 crossref_primary_10_1016_j_ijbiomac_2022_01_153 crossref_primary_10_3390_pr10020242 crossref_primary_10_3390_antiox12040787 crossref_primary_10_1016_j_msec_2021_112436 |
| Cites_doi | 10.1016/j.ejpb.2015.08.004 10.1016/j.clindermatol.2018.03.008 10.1016/j.indcrop.2015.12.038 10.1016/S0140-6736(05)67700-8 10.1016/j.joim.2018.01.001 10.1016/j.ijbiomac.2016.06.075 10.1007/s10856-006-0613-9 10.1016/j.ijpharm.2016.05.013 10.1016/j.cdc.2018.01.005 10.1016/j.reactfunctpolym.2019.02.013 10.1517/14712598.2010.515207 10.1038/nature07039 10.1016/j.ijbiomac.2017.08.142 10.1039/c3tb20940g 10.1016/j.actbio.2016.04.030 10.1016/j.ijbiomac.2017.04.080 10.1016/j.jff.2016.05.007 10.2174/1877382601003020043 10.1016/j.carbpol.2011.12.045 10.1016/j.proghi.2007.06.001 10.1016/j.jep.2016.04.030 10.1016/j.clindermatol.2006.09.007 10.1016/j.ijbiomac.2017.10.056 10.1002/1520-7560(200009/10)16:1+<::AID-DMRR133>3.0.CO;2-Q 10.1016/j.jep.2017.10.016 10.1016/j.carbpol.2016.09.051 10.1016/j.biotechadv.2011.01.005 10.3390/molecules24071226 10.1186/ar2703 10.1056/NEJM199909023411006 10.1016/j.ijbiomac.2012.09.031 10.1002/jbm.a.10396 10.1007/s10924-013-0621-z 10.1016/j.actbio.2013.03.033 10.1016/j.sder.2011.11.007 10.3109/13880209.2015.1028079 10.1016/j.jcm.2011.01.003 10.1186/2193-1801-2-79 |
| ContentType | Journal Article |
| Copyright | 2019 Elsevier B.V. Copyright Elsevier BV Dec 2019 |
| Copyright_xml | – notice: 2019 Elsevier B.V. – notice: Copyright Elsevier BV Dec 2019 |
| DBID | AAYXX CITATION 7SR 8FD JG9 |
| DOI | 10.1016/j.reactfunctpolym.2019.104369 |
| DatabaseName | CrossRef Engineered Materials Abstracts Technology Research Database Materials Research Database |
| DatabaseTitle | CrossRef Materials Research Database Technology Research Database Engineered Materials Abstracts |
| DatabaseTitleList | Materials Research Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Engineering |
| EISSN | 1873-166X |
| ExternalDocumentID | 10_1016_j_reactfunctpolym_2019_104369 S1381514819305577 |
| Genre | Feature |
| GroupedDBID | --K --M -~X .~1 0R~ 123 1B1 1RT 1~. 1~5 29P 4.4 457 4G. 53G 5VS 7-5 71M 8P~ AABXZ AACTN AAEDT AAEDW AAEPC AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARLI AAXUO ABEFU ABFNM ABJNI ABMAC ABXDB ABXRA ABYKQ ACDAQ ACGFS ACIWK ACNNM ACRLP ADBBV ADECG ADEZE ADMUD AEBSH AEKER AENEX AEZYN AFKWA AFRZQ AFTJW AFZHZ AGHFR AGUBO AGYEJ AIEXJ AIKHN AITUG AJBFU AJOXV AJSZI ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FLBIZ FNPLU FYGXN G-Q GBLVA HVGLF HZ~ IHE J1W KOM M41 MAGPM MO0 N9A O-L O9- OAUVE OZT P-8 P-9 PC. Q38 R2- RIG ROL RPZ SCB SDF SDG SES SEW SPC SPCBC SPD SSK SSM SSZ T5K UHS XPP ZMT ~G- AAXKI AAYXX AFJKZ AKRWK CITATION 7SR 8FD JG9 |
| ID | FETCH-LOGICAL-c398t-73002064e5b33f5fe790a9cb2ffac94a43982c1e0f40f066cec87eb4cfcdc27f3 |
| IEDL.DBID | AIKHN |
| ISSN | 1381-5148 |
| IngestDate | Thu Oct 10 16:52:40 EDT 2024 Thu Sep 26 17:36:29 EDT 2024 Fri Feb 23 02:50:59 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Diabetic wounds In vivo Film dressing Wound healing Chitosan |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c398t-73002064e5b33f5fe790a9cb2ffac94a43982c1e0f40f066cec87eb4cfcdc27f3 |
| PQID | 2330968191 |
| PQPubID | 2045408 |
| ParticipantIDs | proquest_journals_2330968191 crossref_primary_10_1016_j_reactfunctpolym_2019_104369 elsevier_sciencedirect_doi_10_1016_j_reactfunctpolym_2019_104369 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-12-01 |
| PublicationDateYYYYMMDD | 2019-12-01 |
| PublicationDate_xml | – month: 12 year: 2019 text: 2019-12-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Amsterdam |
| PublicationPlace_xml | – name: Amsterdam |
| PublicationTitle | Reactive & functional polymers |
| PublicationYear | 2019 |
| Publisher | Elsevier B.V Elsevier BV |
| Publisher_xml | – name: Elsevier B.V – name: Elsevier BV |
| References | Lu, Gao, He, Wu, Liang, Yang, Chen (bb0150) 2017; 156 Riss, Moravec, Niles, Duellman, Benink, Worzella, Minor (bb0165) 2004 Falanga (bb0025) 2005; 366 Güneş, Tıhmınlıoğlu (bb0095) 2017; 102 Bellavite, Marzotto, Bonafini (bb0195) 2018; 16 Gilca, Tiplica, Salavastru (bb0205) 2018; 36 Ali, Mabood, Rizvi, Rehman, Arman, Al-Shidani, Al-Abri, Hussain, Al-Harrasi (bb0070) 2018; 13–14 Colobatiu, Gavan, Mocan, Bogdan, Mirel, Tomuta (bb0115) 2019; 138 Smith, Jacobson (bb0220) 2011; 10 Enoch, Leaper (bb0005) 2008; 26 Harding, Jones, Price (bb0050) 2000; 16 Mocan, Diuzheva, Bădărău, Moldovan, Andruch, Carradori, Campestre, Tartaglia, De Simone, Vodnar, Tiecco, Germani, Crișan, Locatelli, Mocan, Diuzheva, Bădărău, Moldovan, Andruch, Carradori, Campestre, Tartaglia, De Simone, Vodnar, Tiecco, Germani, Crișan, Locatelli (bb0130) 2019; 24 Eming, Brachvogel, Odorisio, Koch (bb0225) 2007; 42 Furman (bb0140) 2015 Bae, Wang, Kurisawa (bb0230) 2013; 1 Găvan, Toiu, Tamaș, Tomuță (bb0120) 2017; 65 Shukla, Kashaw, Jain, Lodhi (bb0100) 2016; 91 Gurtner, Werner, Barrandon, Longaker (bb0015) 2008; 453 Anjum, Arora, Alam, Gupta (bb0075) 2016; 508 Li-Wei, Juan, Huan-Yang, Yan-Ping (bb0215) 2012; 4 Yoon, Lee, Ryu, Jang, Lee, Choi, Choi, Lee, Park, Park, Lee (bb0235) 2016; 38 Xie, Chen, Shen, He, Chen, Luo, Ge, Yuan, Tang, Hou, Jiang (bb0080) 2018; 107 Ezzat, Choucry, Kandil (bb0160) 2016; 54 Pereira, Carvalho, Vaz, Gil, Mendes, Bártolo (bb0110) 2013; 52 Mizuno, Yamamura, Yano, Osada, Saeki, Takimoto, Sakurai, Nimura (bb0190) 2003 Moura, Dias, Carvalho, de Sousa (bb0030) 2013; 9 Zhang, McClain, Lee, Elburki, Yu, Gu, Zhang, Wolff, Johnson, Golub (bb0040) 2016 Patel, Srivastava, Singh, Singh (bb0135) 2018; 107 Mocan, Schafberg, Crișan, Rohn (bb0125) 2016; 24 Tellechea, Leal, Veves, Carvalho (bb0045) 2010; 3 da Silva, Carvalho, Cruz (bb0020) 2010; 10 Morton, Phillips (bb0055) 2012; 31 Rodríguez-Núñez, Madera-Santana, Sánchez-Machado, López-Cervantes, Soto Valdez (bb0085) 2014; 22 Lee, Chang, Yang, Chien, Lai (bb0065) 2012; 88 Jayakumar, Prabaharan, Sudheesh Kumar, Nair, Tamura (bb0105) 2011; 29 Schoukens (bb0060) 2019 Hamilton, Yuan, Rigney, Puckett, Ong, Yang, Elder, Bumgardner (bb0180) 2006; 17 Granica, Agnieszka, Piwowarski, Dudek, Kiss (bb0200) 2016; 188 Chin, Jalil, Ng, Ng (bb0155) 2018; 212 Hilmi, Halim, Hassan, Lim, Noorsal, Zainol (bb0175) 2013; 2 Simard, Galarneau, Marois, Rusu, Hoemann, Poubelle, El-Gabalawy, Fernandes (bb0185) 2009; 11 (bb0145) 2016 Patrulea, Ostafe, Borchard, Jordan (bb0090) 2015; 97 ISO 10993-5 (bb0170) 2009 Gonc, Romano (bb0210) 2016; 83 Singer, Clark (bb0035) 1999; 341 Li, Chen, Kirsner (bb0010) 2007; 25 Morton (10.1016/j.reactfunctpolym.2019.104369_bb0055) 2012; 31 Jayakumar (10.1016/j.reactfunctpolym.2019.104369_bb0105) 2011; 29 Mocan (10.1016/j.reactfunctpolym.2019.104369_bb0130) 2019; 24 Pereira (10.1016/j.reactfunctpolym.2019.104369_bb0110) 2013; 52 Granica (10.1016/j.reactfunctpolym.2019.104369_bb0200) 2016; 188 Găvan (10.1016/j.reactfunctpolym.2019.104369_bb0120) 2017; 65 Hamilton (10.1016/j.reactfunctpolym.2019.104369_bb0180) 2006; 17 Mocan (10.1016/j.reactfunctpolym.2019.104369_bb0125) 2016; 24 Gonc (10.1016/j.reactfunctpolym.2019.104369_bb0210) 2016; 83 Patrulea (10.1016/j.reactfunctpolym.2019.104369_bb0090) 2015; 97 Gilca (10.1016/j.reactfunctpolym.2019.104369_bb0205) 2018; 36 Anjum (10.1016/j.reactfunctpolym.2019.104369_bb0075) 2016; 508 Chin (10.1016/j.reactfunctpolym.2019.104369_bb0155) 2018; 212 Ezzat (10.1016/j.reactfunctpolym.2019.104369_bb0160) 2016; 54 Shukla (10.1016/j.reactfunctpolym.2019.104369_bb0100) 2016; 91 Lee (10.1016/j.reactfunctpolym.2019.104369_bb0065) 2012; 88 Lu (10.1016/j.reactfunctpolym.2019.104369_bb0150) 2017; 156 da Silva (10.1016/j.reactfunctpolym.2019.104369_bb0020) 2010; 10 Eming (10.1016/j.reactfunctpolym.2019.104369_bb0225) 2007; 42 Yoon (10.1016/j.reactfunctpolym.2019.104369_bb0235) 2016; 38 Li (10.1016/j.reactfunctpolym.2019.104369_bb0010) 2007; 25 Gurtner (10.1016/j.reactfunctpolym.2019.104369_bb0015) 2008; 453 Schoukens (10.1016/j.reactfunctpolym.2019.104369_bb0060) 2019 Furman (10.1016/j.reactfunctpolym.2019.104369_bb0140) 2015 Bae (10.1016/j.reactfunctpolym.2019.104369_bb0230) 2013; 1 Riss (10.1016/j.reactfunctpolym.2019.104369_bb0165) 2004 Mizuno (10.1016/j.reactfunctpolym.2019.104369_bb0190) 2003 Falanga (10.1016/j.reactfunctpolym.2019.104369_bb0025) 2005; 366 Smith (10.1016/j.reactfunctpolym.2019.104369_bb0220) 2011; 10 Colobatiu (10.1016/j.reactfunctpolym.2019.104369_bb0115) 2019; 138 Patel (10.1016/j.reactfunctpolym.2019.104369_bb0135) 2018; 107 Güneş (10.1016/j.reactfunctpolym.2019.104369_bb0095) 2017; 102 Zhang (10.1016/j.reactfunctpolym.2019.104369_bb0040) 2016 Enoch (10.1016/j.reactfunctpolym.2019.104369_bb0005) 2008; 26 ISO 10993-5 (10.1016/j.reactfunctpolym.2019.104369_bb0170) Tellechea (10.1016/j.reactfunctpolym.2019.104369_bb0045) 2010; 3 Xie (10.1016/j.reactfunctpolym.2019.104369_bb0080) 2018; 107 Bellavite (10.1016/j.reactfunctpolym.2019.104369_bb0195) 2018; 16 Li-Wei (10.1016/j.reactfunctpolym.2019.104369_bb0215) 2012; 4 Moura (10.1016/j.reactfunctpolym.2019.104369_bb0030) 2013; 9 Ali (10.1016/j.reactfunctpolym.2019.104369_bb0070) 2018; 13–14 Simard (10.1016/j.reactfunctpolym.2019.104369_bb0185) 2009; 11 Rodríguez-Núñez (10.1016/j.reactfunctpolym.2019.104369_bb0085) 2014; 22 Singer (10.1016/j.reactfunctpolym.2019.104369_bb0035) 1999; 341 Harding (10.1016/j.reactfunctpolym.2019.104369_bb0050) 2000; 16 Hilmi (10.1016/j.reactfunctpolym.2019.104369_bb0175) 2013; 2 |
| References_xml | – volume: 138 start-page: 46 year: 2019 end-page: 54 ident: bb0115 article-title: Development of bioactive compounds-loaded chitosan films by using a QbD approach – a novel and potential wound dressing material publication-title: React. Funct. Polym. contributor: fullname: Tomuta – volume: 453 start-page: 314 year: 2008 end-page: 321 ident: bb0015 article-title: Wound repair and regeneration publication-title: Nature. contributor: fullname: Longaker – volume: 22 start-page: 41 year: 2014 end-page: 51 ident: bb0085 article-title: Chitosan/hydrophilic plasticizer-based films: preparation, physicochemical and antimicrobial properties publication-title: J. Polym. Environ. contributor: fullname: Soto Valdez – volume: 3 start-page: 43 year: 2010 end-page: 55 ident: bb0045 article-title: Inflammatory and angiogenic abnormalities in diabetic wound healing: role of neuropeptides and therapeutic perspectives publication-title: Open Circ. Vasc. J. contributor: fullname: Carvalho – volume: 13–14 start-page: 104 year: 2018 end-page: 112 ident: bb0070 article-title: Total polyphenols quantification in Acridocarpus orientalis and Moringa peregrina by using NIR spectroscopy coupled with PLS regression publication-title: Chem. Data Collect. contributor: fullname: Al-Harrasi – year: 2015 ident: bb0140 article-title: Streptozotocin-induced diabetic models in mice and rats publication-title: Curr. Protoc. Pharmacol contributor: fullname: Furman – volume: 10 start-page: 147 year: 2011 end-page: 156 ident: bb0220 article-title: Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials publication-title: J. Chiropr. Med. contributor: fullname: Jacobson – volume: 25 start-page: 9 year: 2007 end-page: 18 ident: bb0010 article-title: Pathophysiology of acute wound healing publication-title: Clin. Dermatol. contributor: fullname: Kirsner – volume: 10 start-page: 1427 year: 2010 end-page: 1439 ident: bb0020 article-title: Role of neuropeptides in skin inflammation and its involvement in diabetic wound healing publication-title: Expert. Opin. Biol. Ther. contributor: fullname: Cruz – volume: 366 start-page: 1736 year: 2005 end-page: 1743 ident: bb0025 article-title: Wound healing and its impairment in the diabetic foot publication-title: Lancet. contributor: fullname: Falanga – volume: 107 start-page: 1888 year: 2018 end-page: 1897 ident: bb0135 article-title: Preparation and optimization of chitosan-gelatin films for sustained delivery of lupeol for wound healing publication-title: Int. J. Biol. Macromol. contributor: fullname: Singh – volume: 83 start-page: 213 year: 2016 end-page: 226 ident: bb0210 article-title: The medicinal potential of plants from the genus Plantago (Plantaginaceae) publication-title: Ind. Crop. Prod. contributor: fullname: Romano – volume: 16 start-page: S47 year: 2000 end-page: S50 ident: bb0050 article-title: Topical treatment: which dressing to choose publication-title: Diabetes Metab. Res. Rev. contributor: fullname: Price – volume: 107 start-page: 93 year: 2018 end-page: 104 ident: bb0080 article-title: Preparation of chitosan-collagen-alginate composite dressing and its promoting effects on wound healing publication-title: Int. J. Biol. Macromol. contributor: fullname: Jiang – volume: 54 start-page: 215 year: 2016 end-page: 224 ident: bb0160 article-title: Antibacterial, antioxidant, and topical anti-inflammatory activities of Bergia ammannioides: a wound-healing plant publication-title: Pharm. Biol. contributor: fullname: Kandil – year: 2019 ident: bb0060 article-title: Bioactive Dressings to Promote Wound Healing contributor: fullname: Schoukens – volume: 97 start-page: 417 year: 2015 end-page: 426 ident: bb0090 article-title: Chitosan as a starting material for wound healing applications publication-title: Eur. J. Pharm. Biopharm. contributor: fullname: Jordan – volume: 65 start-page: 577 year: 2017 end-page: 583 ident: bb0120 article-title: Dry rose petal extracts and compressed lozenges: formulation and NIR – Chemometric quantification of active principles publication-title: Farmacia. contributor: fullname: Tomuță – volume: 9 start-page: 7093 year: 2013 end-page: 7114 ident: bb0030 article-title: Recent advances on the development of wound dressings for diabetic foot ulcer treatment-a review publication-title: Acta Biomater. contributor: fullname: de Sousa – volume: 29 start-page: 322 year: 2011 end-page: 337 ident: bb0105 article-title: Biomaterials based on chitin and chitosan in wound dressing applications publication-title: Biotechnol. Adv. contributor: fullname: Tamura – volume: 102 start-page: 933 year: 2017 end-page: 943 ident: bb0095 article-title: incorporated chitosan films as potential bioactive wound dressing material publication-title: Int. J. Biol. Macromol. contributor: fullname: Tıhmınlıoğlu – volume: 91 start-page: 1110 year: 2016 end-page: 1119 ident: bb0100 article-title: Fabrication of Apigenin loaded gellan gum–chitosan hydrogels (GGCH-HGs) for effective diabetic wound healing publication-title: Int. J. Biol. Macromol. contributor: fullname: Lodhi – volume: 1 start-page: 5371 year: 2013 ident: bb0230 article-title: Injectable biodegradable hydrogels: progress and challenges publication-title: J. Mater. Chem. B contributor: fullname: Kurisawa – volume: 341 start-page: 738 year: 1999 end-page: 746 ident: bb0035 article-title: Cutaneous wound healing publication-title: N. Engl. J. Med. contributor: fullname: Clark – volume: 38 start-page: 59 year: 2016 end-page: 68 ident: bb0235 article-title: Cell recruiting chemokine-loaded sprayable gelatin hydrogel dressings for diabetic wound healing publication-title: Acta Biomater. contributor: fullname: Lee – volume: 16 start-page: 72 year: 2018 end-page: 76 ident: bb0195 article-title: Arnica montana experimental studies: confounders and biases publication-title: J. Integr. Med. contributor: fullname: Bonafini – start-page: 1 year: 2016 end-page: 11 ident: bb0040 article-title: A novel chemically modified curcumin “normalizes” wound-healing in rats with experimentally induced type I diabetes: initial studies publication-title: J. Diabetes Res. contributor: fullname: Golub – volume: 26 start-page: 31 year: 2008 end-page: 37 ident: bb0005 article-title: Basic science of wound healing publication-title: Surgery. contributor: fullname: Leaper – volume: 88 start-page: 809 year: 2012 end-page: 819 ident: bb0065 article-title: Acceleration of wound healing in diabetic rats by layered hydrogel dressing publication-title: Carbohydr. Polym. contributor: fullname: Lai – volume: 156 start-page: 460 year: 2017 end-page: 469 ident: bb0150 article-title: Enhanced antibacterial and wound healing activities of microporous chitosan-Ag/ZnO composite dressing publication-title: Carbohydr. Polym. contributor: fullname: Chen – year: 2009 ident: bb0170 article-title: Biological Evaluation of Medical Devices -- Part 5: Tests for In Vitro Cytotoxicity contributor: fullname: ISO 10993-5 – volume: 4 start-page: 103 year: 2012 end-page: 117 ident: bb0215 article-title: Phytochemicals and their biological activities of plants in Tagetes L publication-title: Chin. Herb. Med. contributor: fullname: Yan-Ping – volume: 11 start-page: R74 year: 2009 ident: bb0185 article-title: Neutrophils exhibit distinct phenotypes toward chitosans with different degrees of deacetylation: implications for cartilage repair publication-title: Arthritis Res. Ther. contributor: fullname: Fernandes – year: 2003 ident: bb0190 article-title: Effect of chitosan film containing basic fibroblast growth factor on wound healing in genetically diabetic mice publication-title: J. Biomed. Mater. Res. A contributor: fullname: Nimura – volume: 42 start-page: 115 year: 2007 end-page: 170 ident: bb0225 article-title: Regulation of angiogenesis: wound healing as a model publication-title: Prog. Histochem. Cytochem. contributor: fullname: Koch – year: 2004 ident: bb0165 article-title: Cell Viability Assays contributor: fullname: Minor – volume: 24 start-page: 579 year: 2016 end-page: 594 ident: bb0125 article-title: Determination of lignans and phenolic components of Schisandra chinensis (Turcz.) Baill. Using HPLC-ESI-ToF-MS and HPLC-online TEAC: contribution of individual components to overall antioxidant activity and comparison with traditional antioxidant assays publication-title: J. Funct. Foods contributor: fullname: Rohn – volume: 188 start-page: 1 year: 2016 end-page: 12 ident: bb0200 article-title: Effects of Geum urbanum L. root extracts and its constituents on polymorphonuclear leucocytes functions. Significance in periodontal diseases publication-title: J. Ethnopharmacol. contributor: fullname: Kiss – volume: 17 start-page: 1373 year: 2006 end-page: 1381 ident: bb0180 article-title: Characterization of chitosan films and effects on fibroblast cell attachment and proliferation publication-title: J. Mater. Sci. Mater. Med. contributor: fullname: Bumgardner – volume: 36 start-page: 338 year: 2018 end-page: 352 ident: bb0205 article-title: Traditional and ethnobotanical dermatology practices in Romania and other Eastern European countries publication-title: Clin. Dermatol. contributor: fullname: Salavastru – volume: 52 start-page: 221 year: 2013 end-page: 230 ident: bb0110 article-title: Development of novel alginate based hydrogel films for wound healing applications publication-title: Int. J. Biol. Macromol. contributor: fullname: Bártolo – volume: 24 start-page: 1226 year: 2019 ident: bb0130 article-title: Liquid phase and microwave-assisted extractions for multicomponent phenolic pattern determination of five Romanian Galium species coupled with bioassays publication-title: Molecules. contributor: fullname: Locatelli – volume: 2 start-page: 79 year: 2013 ident: bb0175 article-title: In vitro characterization of a chitosan skin regenerating template as a scaffold for cells cultivation publication-title: Springerplus. contributor: fullname: Zainol – volume: 212 start-page: 188 year: 2018 end-page: 199 ident: bb0155 article-title: Development and formulation of Moringa oleifera standardised leaf extract film dressing for wound healing application publication-title: J. Ethnopharmacol. contributor: fullname: Ng – volume: 31 start-page: 33 year: 2012 end-page: 37 ident: bb0055 article-title: Wound healing update publication-title: Semin. Cutan. Med. Surg. contributor: fullname: Phillips – volume: 508 start-page: 92 year: 2016 end-page: 101 ident: bb0075 article-title: Development of antimicrobial and scar preventive chitosan hydrogel wound dressings publication-title: Int. J. Pharm. contributor: fullname: Gupta – year: 2016 ident: bb0145 article-title: Rat and Mouse Anesthesia and Analgesia-Formulary and General Drug Information – volume: 97 start-page: 417 year: 2015 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0090 article-title: Chitosan as a starting material for wound healing applications publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2015.08.004 contributor: fullname: Patrulea – volume: 36 start-page: 338 year: 2018 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0205 article-title: Traditional and ethnobotanical dermatology practices in Romania and other Eastern European countries publication-title: Clin. Dermatol. doi: 10.1016/j.clindermatol.2018.03.008 contributor: fullname: Gilca – volume: 83 start-page: 213 year: 2016 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0210 article-title: The medicinal potential of plants from the genus Plantago (Plantaginaceae) publication-title: Ind. Crop. Prod. doi: 10.1016/j.indcrop.2015.12.038 contributor: fullname: Gonc – volume: 366 start-page: 1736 year: 2005 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0025 article-title: Wound healing and its impairment in the diabetic foot publication-title: Lancet. doi: 10.1016/S0140-6736(05)67700-8 contributor: fullname: Falanga – year: 2019 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0060 contributor: fullname: Schoukens – volume: 16 start-page: 72 year: 2018 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0195 article-title: Arnica montana experimental studies: confounders and biases publication-title: J. Integr. Med. doi: 10.1016/j.joim.2018.01.001 contributor: fullname: Bellavite – volume: 91 start-page: 1110 year: 2016 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0100 article-title: Fabrication of Apigenin loaded gellan gum–chitosan hydrogels (GGCH-HGs) for effective diabetic wound healing publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2016.06.075 contributor: fullname: Shukla – volume: 17 start-page: 1373 year: 2006 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0180 article-title: Characterization of chitosan films and effects on fibroblast cell attachment and proliferation publication-title: J. Mater. Sci. Mater. Med. doi: 10.1007/s10856-006-0613-9 contributor: fullname: Hamilton – volume: 508 start-page: 92 year: 2016 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0075 article-title: Development of antimicrobial and scar preventive chitosan hydrogel wound dressings publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2016.05.013 contributor: fullname: Anjum – volume: 13–14 start-page: 104 year: 2018 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0070 article-title: Total polyphenols quantification in Acridocarpus orientalis and Moringa peregrina by using NIR spectroscopy coupled with PLS regression publication-title: Chem. Data Collect. doi: 10.1016/j.cdc.2018.01.005 contributor: fullname: Ali – year: 2015 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0140 article-title: Streptozotocin-induced diabetic models in mice and rats contributor: fullname: Furman – volume: 138 start-page: 46 year: 2019 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0115 article-title: Development of bioactive compounds-loaded chitosan films by using a QbD approach – a novel and potential wound dressing material publication-title: React. Funct. Polym. doi: 10.1016/j.reactfunctpolym.2019.02.013 contributor: fullname: Colobatiu – volume: 65 start-page: 577 year: 2017 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0120 article-title: Dry rose petal extracts and compressed lozenges: formulation and NIR – Chemometric quantification of active principles publication-title: Farmacia. contributor: fullname: Găvan – year: 2004 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0165 contributor: fullname: Riss – volume: 10 start-page: 1427 year: 2010 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0020 article-title: Role of neuropeptides in skin inflammation and its involvement in diabetic wound healing publication-title: Expert. Opin. Biol. Ther. doi: 10.1517/14712598.2010.515207 contributor: fullname: da Silva – volume: 453 start-page: 314 year: 2008 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0015 article-title: Wound repair and regeneration publication-title: Nature. doi: 10.1038/nature07039 contributor: fullname: Gurtner – volume: 107 start-page: 93 year: 2018 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0080 article-title: Preparation of chitosan-collagen-alginate composite dressing and its promoting effects on wound healing publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2017.08.142 contributor: fullname: Xie – volume: 1 start-page: 5371 year: 2013 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0230 article-title: Injectable biodegradable hydrogels: progress and challenges publication-title: J. Mater. Chem. B doi: 10.1039/c3tb20940g contributor: fullname: Bae – volume: 38 start-page: 59 year: 2016 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0235 article-title: Cell recruiting chemokine-loaded sprayable gelatin hydrogel dressings for diabetic wound healing publication-title: Acta Biomater. doi: 10.1016/j.actbio.2016.04.030 contributor: fullname: Yoon – volume: 102 start-page: 933 year: 2017 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0095 article-title: Hypericum perforatum incorporated chitosan films as potential bioactive wound dressing material publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2017.04.080 contributor: fullname: Güneş – volume: 24 start-page: 579 year: 2016 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0125 article-title: Determination of lignans and phenolic components of Schisandra chinensis (Turcz.) Baill. Using HPLC-ESI-ToF-MS and HPLC-online TEAC: contribution of individual components to overall antioxidant activity and comparison with traditional antioxidant assays publication-title: J. Funct. Foods doi: 10.1016/j.jff.2016.05.007 contributor: fullname: Mocan – volume: 26 start-page: 31 year: 2008 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0005 article-title: Basic science of wound healing publication-title: Surgery. contributor: fullname: Enoch – volume: 3 start-page: 43 year: 2010 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0045 article-title: Inflammatory and angiogenic abnormalities in diabetic wound healing: role of neuropeptides and therapeutic perspectives publication-title: Open Circ. Vasc. J. doi: 10.2174/1877382601003020043 contributor: fullname: Tellechea – volume: 88 start-page: 809 year: 2012 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0065 article-title: Acceleration of wound healing in diabetic rats by layered hydrogel dressing publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2011.12.045 contributor: fullname: Lee – start-page: 1 year: 2016 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0040 article-title: A novel chemically modified curcumin “normalizes” wound-healing in rats with experimentally induced type I diabetes: initial studies publication-title: J. Diabetes Res. contributor: fullname: Zhang – volume: 42 start-page: 115 year: 2007 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0225 article-title: Regulation of angiogenesis: wound healing as a model publication-title: Prog. Histochem. Cytochem. doi: 10.1016/j.proghi.2007.06.001 contributor: fullname: Eming – volume: 188 start-page: 1 year: 2016 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0200 article-title: Effects of Geum urbanum L. root extracts and its constituents on polymorphonuclear leucocytes functions. Significance in periodontal diseases publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2016.04.030 contributor: fullname: Granica – volume: 25 start-page: 9 year: 2007 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0010 article-title: Pathophysiology of acute wound healing publication-title: Clin. Dermatol. doi: 10.1016/j.clindermatol.2006.09.007 contributor: fullname: Li – volume: 107 start-page: 1888 year: 2018 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0135 article-title: Preparation and optimization of chitosan-gelatin films for sustained delivery of lupeol for wound healing publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2017.10.056 contributor: fullname: Patel – volume: 16 start-page: S47 year: 2000 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0050 article-title: Topical treatment: which dressing to choose publication-title: Diabetes Metab. Res. Rev. doi: 10.1002/1520-7560(200009/10)16:1+<::AID-DMRR133>3.0.CO;2-Q contributor: fullname: Harding – volume: 212 start-page: 188 year: 2018 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0155 article-title: Development and formulation of Moringa oleifera standardised leaf extract film dressing for wound healing application publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2017.10.016 contributor: fullname: Chin – volume: 156 start-page: 460 year: 2017 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0150 article-title: Enhanced antibacterial and wound healing activities of microporous chitosan-Ag/ZnO composite dressing publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2016.09.051 contributor: fullname: Lu – ident: 10.1016/j.reactfunctpolym.2019.104369_bb0170 contributor: fullname: ISO 10993-5 – volume: 29 start-page: 322 year: 2011 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0105 article-title: Biomaterials based on chitin and chitosan in wound dressing applications publication-title: Biotechnol. Adv. doi: 10.1016/j.biotechadv.2011.01.005 contributor: fullname: Jayakumar – volume: 24 start-page: 1226 year: 2019 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0130 article-title: Liquid phase and microwave-assisted extractions for multicomponent phenolic pattern determination of five Romanian Galium species coupled with bioassays publication-title: Molecules. doi: 10.3390/molecules24071226 contributor: fullname: Mocan – volume: 11 start-page: R74 year: 2009 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0185 article-title: Neutrophils exhibit distinct phenotypes toward chitosans with different degrees of deacetylation: implications for cartilage repair publication-title: Arthritis Res. Ther. doi: 10.1186/ar2703 contributor: fullname: Simard – volume: 341 start-page: 738 year: 1999 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0035 article-title: Cutaneous wound healing publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199909023411006 contributor: fullname: Singer – volume: 52 start-page: 221 year: 2013 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0110 article-title: Development of novel alginate based hydrogel films for wound healing applications publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2012.09.031 contributor: fullname: Pereira – year: 2003 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0190 article-title: Effect of chitosan film containing basic fibroblast growth factor on wound healing in genetically diabetic mice publication-title: J. Biomed. Mater. Res. A doi: 10.1002/jbm.a.10396 contributor: fullname: Mizuno – volume: 4 start-page: 103 year: 2012 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0215 article-title: Phytochemicals and their biological activities of plants in Tagetes L publication-title: Chin. Herb. Med. contributor: fullname: Li-Wei – volume: 22 start-page: 41 year: 2014 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0085 article-title: Chitosan/hydrophilic plasticizer-based films: preparation, physicochemical and antimicrobial properties publication-title: J. Polym. Environ. doi: 10.1007/s10924-013-0621-z contributor: fullname: Rodríguez-Núñez – volume: 9 start-page: 7093 year: 2013 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0030 article-title: Recent advances on the development of wound dressings for diabetic foot ulcer treatment-a review publication-title: Acta Biomater. doi: 10.1016/j.actbio.2013.03.033 contributor: fullname: Moura – volume: 31 start-page: 33 year: 2012 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0055 article-title: Wound healing update publication-title: Semin. Cutan. Med. Surg. doi: 10.1016/j.sder.2011.11.007 contributor: fullname: Morton – volume: 54 start-page: 215 year: 2016 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0160 article-title: Antibacterial, antioxidant, and topical anti-inflammatory activities of Bergia ammannioides: a wound-healing plant publication-title: Pharm. Biol. doi: 10.3109/13880209.2015.1028079 contributor: fullname: Ezzat – volume: 10 start-page: 147 year: 2011 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0220 article-title: Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials publication-title: J. Chiropr. Med. doi: 10.1016/j.jcm.2011.01.003 contributor: fullname: Smith – volume: 2 start-page: 79 year: 2013 ident: 10.1016/j.reactfunctpolym.2019.104369_bb0175 article-title: In vitro characterization of a chitosan skin regenerating template as a scaffold for cells cultivation publication-title: Springerplus. doi: 10.1186/2193-1801-2-79 contributor: fullname: Hilmi |
| SSID | ssj0017166 |
| Score | 2.4880352 |
| Snippet | Delayed wound healing is a major complication of diabetes and the medical treatment of such wounds still remains a challenge. Among the modern wound dressings,... |
| SourceID | proquest crossref elsevier |
| SourceType | Aggregation Database Publisher |
| StartPage | 104369 |
| SubjectTerms | Antioxidants Biocompatibility Biological activity Biomedical materials Chitosan Dehydration Diabetes Diabetic wounds Feasibility studies Film dressing Health services In vivo Wound healing |
| Title | Evaluation of bioactive compounds-loaded chitosan films as a novel and potential diabetic wound dressing material |
| URI | https://dx.doi.org/10.1016/j.reactfunctpolym.2019.104369 https://www.proquest.com/docview/2330968191 |
| Volume | 145 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEB52VxA9iE98k4Me67ZNd9veFFlZFb2osLeQ5iGVtV3dqnjxtzvThy88CEIvLU0TMul83yRfJgB7BiOTfqy1w31NUzeKO7H1reOFyouMRMwpz4y8uOwPb4KzUW_UguNmLwzJKmvfX_n00lvXT7p1b3Ynadq98hBsEO4R0ihrVRi2YQbhyI86MHN0ej68_FhMwJCg3GSE7ztUYBb2P2VeSM1UQRhSTPLxK-1N92Ja-OQkgf4dqn447RKJThZhoaaQ7Khq5RK0TLYM818SC67Aw-AjiTfLLUvSXJZ-jZGCnA5SmjrjXGqjGS0j5FOZMZuO76dM4sWy_NmMmcw0m-QFqYmwtmqONlXshYozXcpns1uGhLccw6twczK4Ph469eEKjuJxVDiUp95HPmJ6Cee2Z00YuzJWiW-tVHEgkahEvvKMawPXIi9RRkWhSQJllVZ-aPkadLI8M-vAjBdh0GSNGyQq4IFNkAqjwSPXRInuabMB_aYfxaTKoSEacdmd-GEAQQYQlQE24LDpdfFtUAj093_9xHZjLVH_nVPhc46RG4Wqm_-vYQvm6K6SuGxDp3h8MjtIVIpkF9oHb95uPRzfAf1i7ew |
| link.rule.ids | 315,783,787,4509,24128,27936,27937,45597,45691 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3JTsMwEB2xSCwHxCoKBXyAY9QkTpvkBqpAZesFkLhZjhcUVJJCA4i_ZyYLmzggIeWUxHHksee9sZ_HAPsGI5NerLXDfU1TN4o7sfWt44XKi4xEzCnPjLwc9gY3wdlt93YK-s1eGJJV1r6_8umlt67vdOrW7IzTtHPlIdgg3COkUdaqMJyGWWQDMY7O2aPT88HwYzEBQ4JykxG-71CBOTj4lHkhNVMFYUgxzkdvtDfdi2nhk5ME-neo-uG0SyQ6WYalmkKyo-ovV2DKZKuw-CWx4Bo8Hn8k8Wa5ZUmay9KvMVKQ00FKE2eUS200o2WEfCIzZtPRw4RJvFiWv5gRk5lm47wgNRHWVs3Rpoq9UnGmS_lsdseQ8JZ9eB1uTo6v-wOnPlzBUTyOCofy1PvIR0w34dx2rQljV8Yq8a2VKg4kEpXIV55xbeBa5CXKqCg0SaCs0soPLd-AmSzPzCYw40UYNFnjBokKeGATpMJo8Mg1UaK72rSg17SjGFc5NEQjLrsXPwwgyACiMkALDptWF986hUB__9dPtBtriXp0ToTPOUZuFKpu_b-GPZgfXF9eiIvT4fk2LNCTSu7Shpni6dnsIGkpkt26U74DvyPv4A |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evaluation+of+bioactive+compounds-loaded+chitosan+films+as+a+novel+and+potential+diabetic+wound+dressing+material&rft.jtitle=Reactive+%26+functional+polymers&rft.au=Colobatiu%2C+Liora&rft.au=Gavan%2C+Alexandru&rft.au=Potarniche%2C+Adrian-Valentin&rft.au=Rus%2C+Vasile&rft.date=2019-12-01&rft.issn=1381-5148&rft.volume=145&rft.spage=104369&rft_id=info:doi/10.1016%2Fj.reactfunctpolym.2019.104369&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_reactfunctpolym_2019_104369 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1381-5148&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1381-5148&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1381-5148&client=summon |