Evaluation of bioactive compounds-loaded chitosan films as a novel and potential diabetic wound dressing material

Delayed wound healing is a major complication of diabetes and the medical treatment of such wounds still remains a challenge. Among the modern wound dressings, film dressings are considered to be one of the major advances in wound management. In the current study, the feasibility of using a previous...

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Published inReactive & functional polymers Vol. 145; p. 104369
Main Authors Colobatiu, Liora, Gavan, Alexandru, Potarniche, Adrian-Valentin, Rus, Vasile, Diaconeasa, Zorita, Mocan, Andrei, Tomuta, Ioan, Mirel, Simona, Mihaiu, Marian
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.12.2019
Elsevier BV
Subjects
Antioxidants
Biocompatibility
Biological activity
Biomedical materials
Chitosan
Dehydration
Diabetes
Diabetic wounds
Feasibility studies
Film dressing
Health services
In vivo
Wound healing
Diabetic wounds
In vivo
Film dressing
Wound healing
Chitosan
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Summary:Delayed wound healing is a major complication of diabetes and the medical treatment of such wounds still remains a challenge. Among the modern wound dressings, film dressings are considered to be one of the major advances in wound management. In the current study, the feasibility of using a previously developed and optimized bioactive compounds-loaded chitosan film formulation as a functional wound dressing material for diabetic wounds was investigated. The antioxidant capacity, as well as the effect of the chitosan films on cell viability was assessed in vitro. Furthermore, the in vivo performance of the films was further evaluated, by using a streptozotocin-induced diabetic rat model. The chitosan film formulation provided a beneficial moist wound environment, reducing the risk of dehydration and favouring the closure of the wounds. Also, it exhibited good antioxidant activity, as well as a proliferative effect and adequate biocompatibility. The in vivo evaluation of the bioactive compounds-loaded chitosan film formulation confirmed that the biofilm stimulated wound contraction and accelerated the wound healing process. The results strongly support that the above mentioned chitosan film seems to be a promising formulation, as well as a potential and novel biomaterial used for wound healing applications.
ISSN:1381-5148
1873-166X
DOI:10.1016/j.reactfunctpolym.2019.104369