DEVELOPMENT AND VALIDATION OF REVERSE PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC AND HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHIC METHODS FOR SIMULTANEOUS ESTIMATION OF MELITRACEN HYDROCHLORIDE AND FLUPENTIXOL HYDROCHLORIDE IN BULK AND COMBINED DOSAGE FORM

• Published in: Journal of liquid chromatography & related technologies Vol. 35; no. 19; pp. 2753 - 2764
• Main Authors: Limgavkar, Ratna S., Trivedi, Priti D., Patel, Archita J.
• Format: Journal Article
• Language: English
• Published: Colchester Taylor & Francis Group 01.01.2012; Taylor & Francis; Taylor & Francis Ltd
• Subjects: Analysis; Biological and medical sciences; Chromatography; Conferences; Dosage; flupentixol hydrochloride; General pharmacology; Guidelines; HPTLC method; Hydrochlorides; ICH Guideline; Linearity; Liquids; Medical sciences; melitracen hydrochloride; method validation; Pharmacology. Drug treatments; RP-HPLC method; Tablets; Validation; method validation; High performance thin layer chromatography; Chemical analysis; Thioxanthene derivatives; Neuroleptic; Psychotropic; HPLC chromatography; Oral form; HPTLC method; ICH Guideline; Tricyclic compound; flupentixol hydrochloride; Reversed phase chromatography; Bulk material; Ultraviolet detector; melitracen hydrochloride; Melitracen; Simultaneous measurement; Dosage form; Antidepressant agent; Tablet; RP-HPLC method; Flupentixol

Sensitive and reproducible reverse-phase high-performance liquid chromatographic and high-performance thin-layer chomatographic methods have been developed for simultaneous estimation of melitracen hydrochloride and flupentixol hydrochloride in bulk and combined tablet dosage form. The methods were...