Pharmacokinetic study of the novel phosphocholine derivative 3-dibutylaminopropylphosphonic acid by LC-MS coupling - Kather, Michel G.; Zeller, Johannes; Plattner, Dietmar; Breit, Bernhard; Kreuzaler, Sheena; Krippner, Guy; Peter, Karlheinz; Eisenhardt, Steffen U.; Kammerer, Bernd (Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2021)
Keywords: Animals; Anti-Inflammatory Agents - blood; Anti-Inflammatory Agents - pharmacokinetics; Anti-Inflammatory Agents - urine; bioavailability; Chromatography, Liquid - methods; complement; Complement System Proteins - immunology; dissociation; drugs; excretion; Humans; inflammation; LC-MS; Mass Spectrometry; metabolites; Myocardial Reperfusion Injury - drug therapy; Myocardial Reperfusion Injury - immunology; pCRP; Pharmacokinetic study; pharmacokinetics; phosphorylcholine; Phosphorylcholine - blood; Phosphorylcholine - pharmacokinetics; Phosphorylcholine - urine; Quantification; Rats; Reperfusion injury; Tandem Mass Spectrometry - methods; urine; Validation; Validation; pCRP; LC-MS; Pharmacokinetic study; Quantification; Reperfusion injury