Development and validation of samples stabilization strategy and LC-MS/MS method for simultaneous determination of clevidipine and its primary metabolite in human plasma: Application to clinical pharmacokinetic study in Chinese healthy volunteers - Zhang, Yujia; Zhao, Shunbo; Zhou, Huan; Ding, Li (Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020)
Keywords: ammonium acetate; ascorbic acid; Asian Continental Ancestry Group; butyrates; China; Chromatography, Liquid - methods; Clevidipine; Drug Stability; electrospray ionization mass spectrometry; emulsions; Ester-containing drugs; esterases; ethyl acetate; formic acid; half life; Humans; hydrolysis; intravenous injection; LC-MS/MS; Linear Models; liquid-liquid extraction; Metabolite; metabolites; methanol; oxidation; Pharmacokinetics; Pyridines - blood; Pyridines - chemistry; Pyridines - pharmacokinetics; Reproducibility of Results; Sensitivity and Specificity; sodium fluoride; Tandem Mass Spectrometry - methods; United Kingdom; China; United Kingdom; Ester-containing drugs; LC-MS/MS; Clevidipine; Pharmacokinetics; Metabolite