Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy - Okumura, Naoki; Kitahara, Miu; Okuda, Hirokazu; Hashimoto, Keisuke; Ueda, Emi; Nakahara, Makiko; Kinoshita, Shigeru; Young, Robert D.; Quantock, Andrew J.; Tourtas, Theofilos; Schlötzer-Schrehardt, Ursula; Kruse, Friedrich; et al. (Investigative ophthalmology & visual science, 2017)
Keywords: Agrin - metabolism; Apoptosis; Cells, Cultured; Collagen Type I - metabolism; Descemet Membrane - metabolism; Descemet Membrane - pathology; Endoplasmic Reticulum - metabolism; Endoplasmic Reticulum - pathology; Endothelium, Corneal - metabolism; Extracellular Matrix Proteins - metabolism; Fibronectins - metabolism; Fuchs' Endothelial Dystrophy - metabolism; Fuchs' Endothelial Dystrophy - pathology; Heat-Shock Proteins - metabolism; Humans; Immunohistochemistry; Membrane Potential, Mitochondrial - physiology; Middle Aged; Oxidative Stress; Protein Aggregation, Pathological - metabolism; Protein Aggregation, Pathological - pathology; Real-Time Polymerase Chain Reaction; Unfolded Protein Response - physiology